N2286

Nonactin

from Streptomyces griseus, ≥98.0% (Total homologs, HPLC)

• 동의어(들): Ammonium ionophore I, Ammonium ionophore
• 실험식(Hill 표기법): C₄₀H₆₄O₁₂
• CAS Number: 6833-84-7
• Molecular Weight: 736.93
• Beilstein: 76434
• EC Number: 229-911-3
• UNSPSC 코드: 51102829
• PubChem Substance ID: 24897566
• NACRES: NA.76

속성

• 생물학적 소스: Streptomyces griseus
• Quality Level: 300
• 설명: Natural macrotetrolide, may contain homologues (like monactin and dinactin)
• 분석: ≥98.0% (Total homologs, HPLC)
• 형태: powder
• solubility: chloroform: soluble 10 mg/mL
• 항생제 활성 스펙트럼: Gram-positive bacteria
• 동작 모드: DNA synthesis | interferes; cell membrane | interferes
• 저장 온도: 2-8°C
• SMILES string: C[C@H]1C[C@@H]2CC[C@@H](O2)[C@@H](C)C(=O)O[C@H](C)C[C@H]3CC[C@H](O3)[C@H](C)C(=O)O[C@@H](C)C[C@@H]4CC[C@@H](O4)[C@@H](C)C(=O)O[C@H](C)C[C@H]5CC[C@H](O5)[C@H](C)C(=O)O1
• InChI: 1S/C40H64O12/c1-21-17-29-9-13-34(49-29)26(6)38(42)46-23(3)19-31-11-15-36(51-31)28(8)40(44)48-24(4)20-32-12-16-35(52-32)27(7)39(43)47-22(2)18-30-10-14-33(50-30)25(5)37(41)45-21/h21-36H,9-20H2,1-8H3/t21-,22+,23+,24-,25-,26+,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-
• InChI key: RMIXHJPMNBXMBU-QIIXEHPYSA-N

설명

일반 설명

Chemical structure: macrolide

애플리케이션

Nonactin is a macrotetrolide that forms complexes with alkali cations, such as potassium and sodium. Nonactin has been reported to inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is an uncoupler of oxidative phosphorylation .

생화학적/생리학적 작용

Nonactin is used as a neutral lipid membrane soluble ammonium (and potassium) ionophore, and to inhibit surface expression of certain heat shock proteins (HSP60) .

기타 정보

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)