SAB3500576
Anti-MFSD2A antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
동의어(들):
Mfsd2A Antibody, Mfsd2A Antibody - Anti-MFSD2A antibody produced in rabbit, Anti-Major facilitator superfamily domain-containing protein 2A, Anti-mfsd2aa
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모든 사진(3)
About This Item
UNSPSC 코드:
12352203
NACRES:
NA.41
추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
종 반응성
mouse, rat, human
기술
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
zebrafish ... mfsd2aa(492810)
일반 설명
Major facilitator superfamily domain containing 2a (Mfsd2a)is a sodium-dependent lysophosphatidylcholine (LPC) transporter. The endothelium of the micro vessels in blood brain barrier express high levels of Mfsd2a.
면역원
MFSD2A antibody was raised against an 18 amino acid peptide near the carboxy terminus of human MFSD2A.
생화학적/생리학적 작용
Major facilitator superfamily domain containing 2a (Mfsd2a) acts as a transporter for the essential omega-3 fatty acid docosahexaenoic acid. It is essential at the blood-brain barrier for postnatal brain growth. A leaky blood-brain barrier from embryonic stages through to adulthood is observed if there is a genetic variation in this gene. Mutation in MFSD2A gene results in microcephaly and ventriculomegaly.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
결합
The action of this antibody can be blocked using blocking peptide SBP3500576.
물리적 형태
Supplied in PBS with 0.02% sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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관련 제품
Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Mfsd2a is critical for the formation and function of the blood-brain barrier
Ben-ZA, et al.
Nature, 507-511 (2014)
Inactivating Mutations in MFSD2A, Required for Omega-3 Fatty Acid Transport in Brain, Cause a Lethal Microcephaly Syndrome
Guemez-GA, et al.
Nature Genetics, 47(7), 809-809 (2015)
The lysolipid transporter Mfsd2a regulates lipogenesis in the developing brain
Chan JP, et al.
PLoS Biology, 16(8), e2006443-e2006443 (2018)
Takuro Iwao et al.
PloS one, 18(2), e0281946-e0281946 (2023-02-17)
Nutrients are actively taken up by the brain via various transporters at the blood-brain barrier (BBB). A lack of specific nutrients in the aged brain, including decreased levels of docosahexaenoic acid (DHA), is associated with memory and cognitive dysfunction. To
Long N Nguyen et al.
Nature, 509(7501), 503-506 (2014-05-16)
Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is essential for normal brain growth and cognitive function. Consistent with its importance in the brain, DHA is highly enriched in brain phospholipids. Despite being an abundant fatty acid in brain
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