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Merck
모든 사진(1)

Key Documents

SAB4501821

Sigma-Aldrich

Anti-TAU antibody produced in rabbit

affinity isolated antibody

동의어(들):

MAPT, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau

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About This Item

MDL number:
UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

형태

buffered aqueous solution

분자량

antigen 78 kDa

종 반응성

mouse, rat, human

농도

~1 mg/mL

기술

ELISA: 1:20000
western blot: 1:500-1:1000

NCBI 수납 번호

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... MAPT(4137)

관련 카테고리

일반 설명

Anti-TAU antibody detects endogenous levels of total TAU protein.
MAPT (microtubule associated protein tau) is located on human chromosome 17q21.3. It is expressed in neurons but is most prominent in axons.

면역원

The antiserum was produced against synthesized peptide derived from human Tau.

Immunogen Range: 501-550

생화학적/생리학적 작용

Removal of MAPT results in developmental delay and learning disability. It participates in the pathology of Alzheimer′s disease (AD). It helps in the assembly and maintenance of microtubule structure.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Robert Prucek et al.
Scientific reports, 11(1), 6240-6240 (2021-03-20)
Targeted and effective therapy of diseases demands utilization of rapid methods of identification of the given markers. Surface enhanced Raman spectroscopy (SERS) in conjunction with streptavidin-biotin complex is a promising alternative to culture or PCR based methods used for such
Youssra K Al-Hilaly et al.
Methods in molecular biology (Clifton, N.J.), 2551, 163-188 (2022-11-01)
Tau is a natively unfolded protein that contributes to the stability of microtubules. Under pathological conditions such as Alzheimer's disease (AD), tau protein misfolds and self-assembles to form paired helical filaments (PHFs) and straight filaments (SFs). Full-length tau protein assembles
Youssra K Al-Hilaly et al.
FEBS letters, 594(5), 944-950 (2019-11-14)
The constituent paired helical filaments (PHFs) in neurofibrillary tangles are insoluble intracellular deposits central to the development of Alzheimer's disease (AD) and other tauopathies. Full-length tau requires the addition of anionic cofactors such as heparin to enhance assembly. We have
Linkage disequilibrium and association of MAPT H1 in Parkinson disease
Skipper L, et al.
American Journal of Human Genetics, 75(4), 669-677 (2004)
The H1c haplotype at the MAPT locus is associated with Alzheimer's disease
Myers AJ, et al.
Human Molecular Genetics, 14(16), 2399-2404 (2005)

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