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Merck
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Key Documents

SAB4502101

Sigma-Aldrich

Anti-TNNI3K antibody produced in rabbit

affinity isolated antibody

동의어(들):

Cardiac ankyrin repeat kinase TNNI3K, Serine/threonine-protein kinase TNNI3K TNNI3-interacting kinase

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

형태

buffered aqueous solution

분자량

antigen 104 kDa

종 반응성

rat, mouse, human

농도

~1 mg/mL

기술

ELISA: 1:10000
immunohistochemistry: 1:50-1:100

NCBI 수납 번호

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... TNNI3K(51086)

일반 설명

Anti-TNNI3K antibody detects endogenous levels of total TNNI3K protein.
The TNNI3K (TNNI3 interacting kinase) gene is a novel cardiac troponin I-interacting kinase gene and is mapped to human chromosome 1p31.1. The gene is expressed in cardiomyocytes. The encoded protein belongs to mitogen-activated protein kinase kinase kinase (MAPKKK) family. Tnni3k consists of seven to ten ankyrin repeats at the N terminal, a Ser/Thr and Tyr kinase domain, and a Ser-rich domain at the C-terminal.

면역원

The antiserum was produced against synthesized peptide derived from human TNNI3K.

Immunogen Range: 301-350

생화학적/생리학적 작용

Overexpression of TNNI3K (TNNI3 interacting kinase) may induce and increase cardiac myogenesis and performance respectively. It also might inhibit ventricular remodeling, caused by ischemia. TNNI3K might be associated with the development of cardiac hypertrophy. TNNI3K is known to be associated with atrioventricular conduction disease, acute coronary syndrome and obesity.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Overexpression of Cardiac-Specific Kinase TNNI3K Promotes Mouse Embryonic Stem Cells Differentiation into Cardiomyocytes.
Wang Y
Cellular Physiology and Biochemistry, 41(1), 381-398 (2017)
TNNI3K could be a novel molecular target for the treatment of cardiac diseases.
Lai ZF
Recent Patents on Cardiovascular Drug Discovery, 4(3), 203-210 (2009)

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