SAB5200022

Monoclonal Anti-CACNA1D antibody produced in mouse

clone S48A-9, 1 mg/mL, purified immunoglobulin

• 동의어(들): Anti-CACH3, Anti-CACN4, Anti-CACNA 1D, Anti-CACNL1A2, Anti-Cav1.3, S48A-9, Anti-oltage dependent L type calcium channel subunit alpha 1D
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• 결합: unconjugated
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: S48A-9, monoclonal
• 형태: buffered aqueous glycerol solution
• 분자량: antigen predicted mol wt 250 kDa
• 종 반응성: human, rat, mouse
• 농도: 1 mg/mL
• 기술: immunocytochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• 동형: IgG2aκ
• NCBI 수납 번호: NP_058994.1
• UniProt 수납 번호: Q01668
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: rat ... Cacna1d(29716)

설명

일반 설명

Calcium channel, L type α-1 polypeptide isoform 2 (CACNA1D) is expressed in many tissues and possesses six transmembrane segments, along with a loop lining the pore of the channel. The gene encoding CACNA1D is localized on human chromosome 3p14.3.

특이성

Detects ~250 kDa. No cross-reactivity against Cav1.2

면역원

Fusion protein amino acids 859-875 of rat Cav1.3, Accession Number P27732

애플리케이션

Monoclonal Anti-CACNA1D antibody produced in mouse has been used in immunocytochemistry.

생화학적/생리학적 작용

Calcium channel, L type α-1 polypeptide isoform 2 (CACNA1D) is crucial for the functioning of the brain and in hearing. It gets activated at a fast rate and withstands high inward Ca²⁺ currents even at threshold voltages. CACNA1D aids in dendritic signals linked to mitochondrial stress in the brain and is important for estrogen-stimulated Ca²⁺ influx. Studies have shown that in atrial myocytes, the C terminus of the channel translocates to the nucleus and regulates Ca²⁺-activated K⁺ channels. CACNA1D was shown to be upregulated in endometrial cancer and its knockdown showed a reduction in cell proliferation in vitro. Mutations in the gene encoding it has been associated with aldosterone-producing adenomas (APAs), where it leads to the formation of small adenomas.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable