SRP2140

PPAR γ, ligand binding domain (204-477), GST tagged human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

• 동의어(들): CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma
• UNSPSC 코드: 12352200
• NACRES: NA.26

속성

• 생물학적 소스: human
• 재조합: expressed in E. coli
• 분석: ≥80% (SDS-PAGE)
• 형태: frozen liquid
• 분자량: ~57.8 kDa
• 포장: pkg of 10 μg
• 저장 조건: avoid repeated freeze/thaw cycles
• 농도: 450 μg/mL
• 색상: clear colorless
• NCBI 수납 번호: NM_138712
• UniProt 수납 번호: P37231
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... PPARG(5468)

설명

생화학적/생리학적 작용

There is evidence that a group of closely related nuclear receptors, called peroxisome proliferator-activated receptors (PPARs), may be involved in chronic diseases such as diabetes, obesity, artherosclerosis and cancer. The PPARs were first cloned as the nuclear receptors that mediate the effects of synthetic compounds called peroxisome proliferators on gene transcription. It soon became clear that eicosanoids and fatty acids can also regulate gene transcription through PPARs. They bind a specific element in the promoter region of target genes only as a heterodimer with the receptor for 9- cis retinoic acid, RXR (retinoid X receptor). Binding of the ligand of either receptor can activate the complex, but binding of both ligands simultaneously is more potent. Three PPAR isotypes have been identified: α, β (also called NUC1) and γ. PPARα is expressed most in brown adipose tissue and liver, then kidney, heart and skeletal muscle. PPARγ is mainly expressed in adipose tissue, and to a lesser extent in colon, the immune system and the retina. PPARβ is found in many tissues but the highest expression is in the gut, kidney and heart. PPARγ influences the storage of fatty acids in the adipose tissue. With the C/EBP transcription factors, PPARγ is part of the adipocyte differentiation program that induces the maturation of pre-adipocytes into fat cells. Most of the PPARγ target genes in adipose tissue are directly implicated in lipogenic pathways, including lipoprotein lipase (LPL), adipocyte fatty acid binding protein (A-FABP or AP2), acyl-CoA synthase and fatty acid transport protein (FATP). In addition, PPARγ is a direct target gene of the transcription factor sterol response element binding protein 1 (SREBP1) emphasizing the cooperative and additive functions between these two types of receptor.

물리적 형태

Clear and colorless frozen liquid solution

제조 메모

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable