추천 제품
생물학적 소스
human
재조합
expressed in E. coli
분석
≥98% (HPLC)
≥98% (SDS-PAGE)
형태
lyophilized
분자량
~9.8 kDa
포장
pkg of 50 μg
저장 조건
avoid repeated freeze/thaw cycles
불순물
endotoxin, tested
NCBI 수납 번호
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
human ... PTHLH(5744)
일반 설명
Parathyroid Hormone-like related Protein (PTHrP) is a member of the Parathyroid hormone family that is expressed in the mammary gland. It is known as a potent inhibitor of chondrocyte maturation. PTHrP is expressed by periarticular perichondrial cells and exerts its biological activity on PP-R expressing cells. During endochondral bone development PTHrP plays a major role in suppressing the onset of hypertrophic differentiation. It is also responsible for most cases of humoral hypercalcemia of malignancy. Recombinant Human PTHrP is a 9.8 kDa protein consisting of 86 amino acid residues.
Recombinant Human PTHrP is a 9.8 kDa protein consisting of 86 amino acid residues.
애플리케이션
The human parathyroid hormone-like related protein (PTHrP) has been used as an osteoarthritis-associated factor regulating hypertrophic differentiation of human chondrocytes. It has also been used in the regulation of the expression of Smpd3 (Sphingomyelin phosphodiesterase 3) in chondrocytes.
생화학적/생리학적 작용
The gene PTHrP (parathyroid hormone-like related protein) encodes a protein involved in skeletal development. It binds to the receptor activated by PTH (parathyroid hormone) and functions in smooth muscle relaxation, regulation of cellular proliferation and differentiation. It also regulates endochondral bone development and proliferation of growth plate chondrocytes. It regulates fetal blood calcium and placental calcium transport. It has been associated with malignant hypercalcemia. Mutation in this gene has been associated with brachydactyly type E2 (BDE2).
물리적 형태
Sterile filtered and lyophilized without additives.
재구성
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
PTHrP and skeletal development.
Kronenberg HM
Annals of the New York Academy of Sciences, 1068, 1-13 (2006)
The cytology of the gametes and fertilization of Allomyces macrogynus.
Pommerville J and Fuller MS
Archives of Microbiology, 109, 21-30 (1976)
Mark M Kushnir et al.
Clinical chemistry, 62(1), 218-226 (2015-11-19)
Parathyroid hormone-related peptide (PTHrP) is involved in activating pathways, allowing tumor cells to form bone metastases. Measurement of PTHrP is used for the diagnosis and clinical management of patients suspected of hypercalcemia of malignancy. We developed an LC-MS/MS method for
Exome sequencing reveals a novel PTHLH mutation in a Chinese pedigree with brachydactyly type E and short stature.
Wang J
Clinica Chimica Acta; International Journal of Clinical Chemistry, 446:9-44614 (2015)
Huiren Tao et al.
PloS one, 6(8), e23199-e23199 (2011-09-03)
p38 mitogen-activated protein kinase (MAPK) acts downstream in the signaling pathway that includes receptor activator of NF-κB (RANK), a powerful inducer of osteoclast formation and activation. We investigated the role of p38 MAPK in parathyroid hormone related protein (PTHrP)-induced osteoclastogenesis
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