T7830

TFLLR-NH2 trifluoroacetate salt

>98% (HPLC)

• 동의어(들): L-Threonyl-L-phenylalanyl-L-leucyl-L-leucyl- L-argininamide trifluoroacetate salt, Thr-Phe-Leu-Leu-Arg-NH2 trifluoroacetate salt
• 실험식(Hill 표기법): C₃₁H₅₃N₉O₆ · xC₂HF₃O₂
• CAS Number: 1313730-19-6
• Molecular Weight: 647.81 (free base basis)
• MDL number: MFCD05663482
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329826874
• NACRES: NA.77

속성

• 분석: >98% (HPLC)
• 형태: lyophilized powder
• 색상: white to tan
• solubility: H₂O: >2 mg/mL
• 저장 온도: −20°C
• SMILES string: OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
• InChI: 1S/C31H53N9O6.C2HF3O2/c1-17(2)14-22(27(43)37-21(26(33)42)12-9-13-36-31(34)35)38-28(44)23(15-18(3)4)39-29(45)24(16-20-10-7-6-8-11-20)40-30(46)25(32)19(5)41;3-2(4,5)1(6)7/h6-8,10-11,17-19,21-25,41H,9,12-16,32H2,1-5H3,(H2,33,42)(H,37,43)(H,38,44)(H,39,45)(H,40,46)(H4,34,35,36);(H,6,7)/t19-,21+,22+,23+,24+,25+;/m1./s1
• InChI key: QVNWOGSDGQDGHP-MKVNCOEFSA-N

설명

Amino Acid Sequence

Thr-Phe-Leu-Leu-Arg-NH2

애플리케이션

TFLLR-NH₂ trifluoroacetate salt has been used as a protease-activated receptor-1 (PAR-1) agonist to study its effects on hippocampal CA1 pyramidal neurons and Swell1 knock out mice (cKO).

생화학적/생리학적 작용

TFLLR-NH2 is a protease-activated receptor (PARs) agonist which is more selective to PAR-1 than SFLLRN-NH2. Protease-activated receptors (PARs) are present on various organs including, plateles, mast cell, gallblader, oesophagus etc, and regulate various physiological processes including human platelet aggregation, vascular contraction/relaxation, and an increase in endothelial permeability. Recent papers indicated that PAR′s are also involved in sensory processing. Specificly PAR ligands enhance glutamatergic excitatory transmission in substantia gelatinosa (SG) neurons of adult rat spinal cord slices.

제조 메모

TFLLR-NH2 trifluoroacetate is soluble in water at a concentration that is greater than 2 mg/ml.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable