1151855

Curcumin

United States Pharmacopeia (USP) Reference Standard

• 동의어(들): (E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane, Diferulylmethane, Natural Yellow 3
• Linear Formula: [HOC₆H₃(OCH₃)CH=CHCO]₂CH₂
• CAS Number: 458-37-7
• Molecular Weight: 368.38
• 색상 지수 번호: 75300
• Beilstein: 2306965
• MDL number: MFCD00008365
• UNSPSC 코드: 41116107
• PubChem Substance ID: 329749465
• NACRES: NA.24

속성

• Grade: pharmaceutical primary standard
• vapor density: 13 (vs air)
• API family: curcumin
• 제조업체/상표: USP
• 응용 분야: pharmaceutical (small molecule)
• 형식: neat
• SMILES string: COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O
• InChI: 1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
• InChI key: VFLDPWHFBUODDF-FCXRPNKRSA-N

설명

일반 설명

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

애플리케이션

• Evaluating the dose-dependent effects of curcumin nano-micelles on rumen fermentation, nitrogen metabolism, and nutrient digestibility in heat-stressed fattening lambs: This study investigates the application of high-purity curcumin in improving animal health and productivity under climate stress, highlighting its potential as a bioactive compound in veterinary nutritional research (Bokharaeian et al., 2024).


• Curcumin reduces myocardial ischemia-reperfusion injury, by increasing endogenous H2S levels and further modulating m6A: This research underscores curcumin′s bioactive role in cardiovascular protection, offering insights into its mechanism of action within cell signaling pathways related to heart health (Cui et al., 2024).


• Targeting CD8+ T cells with natural products for tumor therapy: Revealing insights into the mechanisms: This review discusses the therapeutic applications of curcumin in cancer treatment, focusing on its interaction with cellular mechanisms and its potential as a molecular marker in immunotherapy (Wang et al., 2024).


• Senolytic effects on dental pulp stem cell′s proliferation and differentiation during long-term expansion: This article examines curcumin′s potential to influence cell growth and repair processes, pertinent to its research applications in dental and regenerative medicine (Wang et al., 2024).


• Future aspects of plant derived bioactive metabolites as therapeutics to combat benign prostatic hyperplasia: This review highlights curcumin′s role as a leading natural compound in pharmacological research, focusing on its anti-inflammatory and neuroprotective properties for treating conditions like benign prostatic hyperplasia (Krishnamoorthi et al., 2024).

생화학적/생리학적 작용

A natural phenolic compound responsible for the yellow color of turmeric. Potent anti-tumor agent that acts against highly diverse tumor-specific pathways. Anti-inflammatory and anti-oxidant. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cyclooxygenase (COX-2) and 5-lipoxygenase (5-LOX).

A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Curcumin has been cited as a potential chemopreventive agent, in addition to its chemotherapeutic activity. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.

분석 메모

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

기타 정보

Sales restrictions may apply.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable