[A study in extraction method of buprenorphine in urine].

The extraction method for separating buprenorphine from urine was described. Buprenorphine was extracted with chloroform at pH7 or with SPE (extracted by organic support 401 at pH10.8, then eluted with chloroform), finally determined by GC-NPD. The extracted yields of the analyte in specimens were 86.6% by solution-phase extraction and 83.0% by solid-phase extraction (SPE) respectively. These two methods are simple and accurate for separating buprenorphine from urine.