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Merck
  • Catalytic asymmetric vinylogous Mannich-type (AVM) reaction of nonactivated α-angelica lactone.

Catalytic asymmetric vinylogous Mannich-type (AVM) reaction of nonactivated α-angelica lactone.

Organic letters (2011-05-21)
Lin Zhou, Lili Lin, Jie Ji, Mingsheng Xie, Xiaohua Liu, Xiaoming Feng
초록

A direct highly diastereo- and enantioselective asymmetric vinylogous Mannich-type (AVM) reaction of aldimines with nonactivated natural α-angelica lactone has been successfully developed. It was demonstrated that the nonactivated natural α-angelica lactone is a useful vinylogous nucleophile to give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives. The N,N'-dioxide L2-Sc(III) complex is efficient toward the obtention of a range of corresponding products with adjacent quaternary and tertiary stereocenters in excellent dr and ee values.

MATERIALS
제품 번호
브랜드
제품 설명

Sigma-Aldrich
α-Angelica lactone, 98%, FG
Sigma-Aldrich
α-Angelica lactone, 98%