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Ultrasensitive SMC® Neurology Immunoassays

High Sensitivity Immunoassays to Detect Neurology Biomarkers

Protein biomarkers have emerged as a prominent focus of neurology research, particularly for conditions like Alzheimer’s disease, multiple sclerosis, and traumatic brain injury. As recent efforts have shifted towards studying serum and plasma samples for key biomarkers because they are more accessible than cerebrospinal fluid, SMC® high sensitivity immunoassay kits coupled with the SMCxPRO® immunoassay system have emerged as powerful tools that facilitate the earlier detection of critical neurological biomarkers in these sample types.

Leverage the ability of SMC® high sensitivity immunoassay kits to accurately and reliably measure key neurology protein analytes from health through disease to take your research to the next level.

Our growing menu of ultrasensitive assays for key neuroscience biomarkers includes:

  • Phospho-Tau (T217)
  • Phospho-Tau (T231)
  • Neurofilament Light Chain (NF-L)
  • Total Tau
  • Phospho-Tau (T181)
  • Amyloid Beta
  • Total Alpha Synuclein
  • Phospho-Alpha Synuclein (S129)
  • Brain-Derived Neurotrophic Factor (BDNF)
  • Glial Fibrillary Acidic Protein (GFAP)
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NEW: SMC® Human pTau217 and SMC® Human pTau231 High Sensitivity Kits

Tau biomarkers, released from diseased and damaged neurons, aid in identifying abnormal tau protein accumulation, a key feature of neurodegenerative diseases. Detecting and measuring these proteins at low levels provides insights into the discovery and progression of such disorders, enabling the development and evaluation of therapies that manage these conditions.

Ultrasensitive SMC® immunoassay technology on the SMCxPRO® platform enables researchers to study low-abundant blood-based neurodegenerative biomarkers like Tau and profile subtle changes in expression. We have now added pTau217 and pTau231 to our growing list of neuroscience kits!

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Representative Kit Data: Plasma pTau217 and pTau231 Measurements

2 graphs showing tau protein measurements in Alzheimer’s disease (AD) samples compared to controls using the ultrasensitive SMC® pTauT217 and pTau231 kits. Graph on the left shows pTau217 measurements with a p value of 0.16, control samples are around 20 pg/mL while AD samples are around 25 pg/mL. Graph on the right shows pTau231 measurements with a p value of <0.0001, control samples are around 25 pg/mL while AD samples are around 125 pg/mL.

Figure 1.Ten healthy (control) human plasma samples compared to 10 Alzheimer’s Disease (AD) human plasma samples using the SMC® pTauT217 and pTau231 kits. Displayed p values were obtained using the Mann-Whitney test.

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