CRISPR/Cas technologies have unlocked vast genome editing possibilities in a wide variety of cells and tissues. As a research tool, CRISPR/Cas9 has been used as a set of programable molecular scissors, making double-stranded DNA breaks (DSBs) almost anywhere in the genome. A nuclease deficient version of Cas9 called dead Cas9 or dCas9 is becoming a versatile tool in the arsenal of scientists who want to explore and identify other regions of the genome without making DSBs. Here we will describe some of the uses of the CRISPR/Cas system that is allowing researchers to uncover, enrich, and discover new biomarkers and pathways important for diagnostic applications.
Casey Jowdy, Ph.D.
CRISPR Product Specialist, Genome Editing Tools
Casey Jowdy obtained his Ph.D. in Molecular genetics from Ohio State University. Over the past 15 years, Casey has gained research experience through his doctoral program, postdoctoral fellow, and industry-related work where he worked on projects related to the genetics of the central nervous system development, heart failure, cancer and rare undiagnosed human diseases. Currently, Casey works in the functional genomics group. In his present role, he works with a team of scientists to use CRISPR/Cas9 genome editing tools to elucidate the molecular mechanisms of gene function. Our life science business offers a complete set of products for the interrogation of complex biological questions.
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