Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel betacoronavirus causing Coronavirus disease 2019 (COVID-19). There is an urgent need to understand the humoral immune responses to SARS-CoV-2 and how they contribute to disease severity and vaccine-induced immunity. Humoral immune responses targeting SARS-CoV-2 viral antigens have been characterized by high-resolution mapping of the antibody responses in adults naturally infected with SARS-CoV-2, children and adults with no history of SARS-CoV-2 infection, and adults immunized with a two-dose COVID-19 messenger RNA (mRNA) vaccine. Most infected and vaccinated adults developed robust antibody responses (in order of prevalence: IgG>IgM>IgA) targeting spike (S) and nucleocapsid (N) proteins of the virus using MILLIPLEX® multiplexed bead-based binding assays. Individuals who had prior infection showed significantly higher antibody levels to SARS-CoV-2 after a single vaccine dose. While uninfected infants did not have high levels of SARS-CoV-2 cross-reactive antibodies, many children and adults had cross-reactive antibodies that recognize multiple viral antigens. These findings provide insights into SARS-CoV-2 antibody responses after infection, vaccination, and in unexposed populations of children and adults, which can facilitate future vaccine designs.
Our expert speaker, Todd Bradley, director of Immunogenomics at Children’s Mercy Research Institute in Kansas City, Missouri, will:
For Research Use Only. Not For Use In Diagnostic Procedures.
Todd Bradley, Ph.D.
Children’s Mercy Research Institute
Director of Immunogenomics
Dr. Bradley is director of Immunogenomics in the Genomic Medicine Center at the Children’s Mercy Research Institute, Children’s Mercy Hospital, in Kansas City, Missouri, USA. He is also an assistant professor of pediatrics at the University of Missouri-Kansas City School of Medicine and an assistant professor of pediatrics and pathology and laboratory medicine at the University of Kansas Medical Center. He is a pediatric genomic immunologist who directs a research laboratory determined to understand how immune responses are regulated in order to develop tools to engineer immunity. His lab uses genomic technologies to dissect the molecular and cellular mechanisms that shape the immune response and to discover how human genetics impact immunity, with the goal of improving vaccines and immunotherapies. Prior to joining Children’s Mercy, Dr. Bradley was an assistant professor of medicine at the Human Vaccine Institute at Duke University Medical Center, in Durham, North Carolina, USA.
Session 1:presented August 4, 2021
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