Process Development and Intensification for Ultrafiltration/Diafiltration of Viral Vectors

WEBINAR

Fast and efficient processes with reliable scale-up capabilities are essential for viral vector manufacturing. The primary tangential flow filtration (TFF) — step-through ultrafiltration and diafiltration (UF/DF) — can intensify the purification process prior to chromatography steps.

We will explore two operating strategies, transmembrane pressure (TMP) and permeate control, while considering their impact on process time, viral yield, and impurity removal. We will also compare the performance of commercially available single-use TFF modules for processing viral vectors. These insights offer a foundation for process development and optimization of processing viral vectors.

In this webinar, you will learn about:

• The methods to develop, optimize and scale up a TFF process for viral vector manufacturing with different operating strategies
• Intensifying the downstream purification process for viral vectors
• Process performance characteristics of different single-use technologies available for viral vector manufacturing