MilliporeSigma

COL4A3

collagen, type IV, alpha 3 (Goodpasture antigen)

Synonyms:
Species:
UniProtKB ID:
Gene ID:
  • Human(1285) Summary: Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jun 2010]
  • Mouse(12828) collagen, type IV, alpha 3
  • Rat(363265) collagen, type IV, alpha 3
  • chicken(424797) collagen, type IV, alpha 3 (Goodpasture antigen)
  • cow(317711) collagen, type IV, alpha 3 (Goodpasture antigen)
  • domestic cat(101087512) collagen, type IV, alpha 3 (Goodpasture antigen)
  • Zebrafish(553354) collagen, type IV, alpha 3
  • dog(403842) collagen, type IV, alpha 3 (Goodpasture antigen)
  • Horse(100037402) collagen, type IV, alpha 3 (Goodpasture antigen)
  • naked mole-rat(101709004) collagen, type IV, alpha 3 (Goodpasture antigen)
  • Domestic Rabbit(100009082) collagen, type IV, alpha 3 (Goodpasture antigen)
  • sheep(443526) collagen, type IV, alpha 3 (Goodpasture antigen)
  • domestic guinea pig(100732315) collagen, type IV, alpha 3 (Goodpasture antigen)
  • sheep(101102790) collagen, type IV, alpha 3 (Goodpasture antigen)

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Collagen IV α3 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
immunofluorescence

immunohistochemistry
Anti-Collagen IV α3 (Cleaved-Leu1425) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
western blot
Monoclonal Anti-Collagen, Type IV antibody produced in mouse, clone COL-94, ascites fluid,
Species Reactivity
human
Application
ELISA
dot blot

immunohistochemistry

microarray

Proteins

Product Number
Description
Species
Collagen from human placenta, Bornstein and Traub Type I (Sigma Type VIII), powder,
Species
human, cow
Collagen from human placenta, Bornstein and Traub Type IV, powder,
Species
human
Collagen from Engelbreth-Holm-Swarm murine sarcoma basement membrane, Type IV (Miller), lyophilized powder, BioReagent, suitable for cell culture,
Species
mouse
Collagen from human placenta, Bornstein and Traub Type IV, powder,
Species
human
Collagen from human placenta, Bornstein and Traub Type IV, solution, suitable for cell culture, High Performance,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human COL4A3,
Species
human