MilliporeSigma

CYP1A2

cytochrome P450, family 1, subfamily A, polypeptide 2

Synonyms:
CP12, P3-450, P450(PA)
Species:
UniProtKB ID:
Gene ID:
  • Human(1544) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008]
  • Mouse(13077) cytochrome P450, family 1, subfamily a, polypeptide 2
  • Rat(24297) cytochrome P450, family 1, subfamily a, polypeptide 2
  • domestic guinea pig(100135513) cytochrome P450, family 1, subfamily a, polypeptide 2
  • domestic cat(554345) cytochrome P450 1A2
  • chicken(414856) cytochrome P450, family 1, subfamily A, polypeptide 2
  • cow(503552) cytochrome P450, family 1, subfamily A, polypeptide 2
  • dog(494010) cytochrome P450, family 1, subfamily A, polypeptide 2

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Cytochrome P450 Enzyme CYP1A2 Antibody, serum, Chemicon®,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-CYP1A2 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-CYP1A2 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Chloramphenicol, γ-irradiated,
Species
human
Anisaldehyde solution, ,
Species
human
3-Methylquinoline, 99%,
Species
human
2-Ethylnaphthalene, ≥99%,
Species
human
γ-Undecalactone, ≥98%, FCC, FG,
Species
human

Proteins

Product Number
Description
Species
Cytochrome P450 human, 1A2 Isozyme Microsomes, with P450 Reductase and cytochrome b5, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4),
Species
human
CypExpress 1A2 Cytochrome P450 human, ,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human CYP1A2,
Species
human