MilliporeSigma

ESR1

estrogen receptor 1

Synonyms:
ER, ESR, ESRA, ESTRR, Era, NR3A1
Species:
UniProtKB ID:
Gene ID:
  • Human(2099) Summary: This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. [provided by RefSeq, Jul 2008]
  • Mouse(13982) estrogen receptor 1 (alpha)
  • Rat(24890) estrogen receptor 1
  • domestic cat(552888) estrogen receptor 1
  • dog(403640) estrogen receptor 1
  • chicken(396099) estrogen receptor 1
  • Thale Cress(837856) ethylene-responsive transcription factor ESR1
  • Horse(791249) estrogen receptor 1
  • Zebrafish(259252) estrogen receptor 1
  • cow(407238) estrogen receptor 1
  • Goat(100860768) estrogen receptor 1
  • sheep(443228) estrogen receptor 1
  • domestic guinea pig(100713276) estrogen receptor 1

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Small Molecule - Activator

Product Number
Description
Species
4-Phenylazophenol, 98%,
Species
human
β-Nicotinamide adenine dinucleotide sodium salt, ,
Species
human
trans-4-Stilbenemethanol, ,
Species
human, rat
cis-Stilbene, 96%,
Species
human, rat
β-Nicotinamide adenine dinucleotide hydrate, suitable for cell culture, ≥96.5% (HPLC), ≥96.5% (spectrophotometric assay), from yeast,
Species
human

Small Molecule - Agonist

Product Number
Description
Species
Diethylstilbestrol, United States Pharmacopeia (USP) Reference Standard,
Species
human
Ethinylestradiol, British Pharmacopoeia (BP) Assay Standard,
Species
human
Mestranol, United States Pharmacopeia (USP) Reference Standard,
Species
human
Ethinyl Estradiol, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
β-Estradiol 17-cypionate, ,
Species
human

Small Molecule - Allosteric Modulator

Product Number
Description
Species
Tamoxifen citrate for performance test, European Pharmacopoeia (EP) Reference Standard,
Species
human
Tamoxifen, analytical standard,
Species
human
Tamoxifen citrate, European Pharmacopoeia (EP) Reference Standard,
Species
human
Tamoxifen citrate, British Pharmacopoeia (BP) Reference Standard,
Species
human
Tamoxifen, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
4-tert-Octylphenol, analytical standard,
Species
mouse
2-Chloro-4,6-diamino-1,3,5-triazine, 95%,
Species
mouse
Dibutyl phthalate, 99%,
Species
mouse
4-tert-Octylphenol, 97%,
Species
mouse
Benzyl butyl phthalate, 98%,
Species
mouse

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-ESR1 (Ab-104) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-ESR1 (Ab-118) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

western blot
Anti-phospho-Estrogen Receptor-α (pSer102) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Monoclonal Anti-ESR1 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL1196, purified immunoglobulin, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

western blot
Monoclonal Anti-ESR1 antibody produced in mouse, clone 6B6, ascites fluid,
Species Reactivity
human
Application
ELISA
immunofluorescence

immunohistochemistry

western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Bicyclohexyl, 99%,
Species
human
Biphenyl, ReagentPlus®, 99.5%,
Species
human
Biphenyl, ≥99%,
Species
human
4′-Hydroxy-4-biphenylcarbonitrile, 97%,
Species
human
4,4′-Dihydroxybiphenyl, 97%,
Species
human

Small Molecule - Ligand

Product Number
Description
Species
Progesterone, VETRANAL®, analytical standard,
Species
human
4-Hydroxyestradiol, ,
Species
rat, human
Tamoxifen, ≥99%,
Species
human, rat
Testosterone, ≥98%,
Species
mouse, human, rat
Progesterone, meets USP testing specifications,
Species
mouse, human, rat

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
α-Estradiol, powder, ≥98% (TLC),
Species
human, rat
Medroxyprogesterone 17-acetate, ≥97% (HPLC),
Species
human, rat
Estradiol, meets USP testing specifications,
Species
human, mouse, rat
β-Estradiol, analytical standard,
Species
human, mouse, rat
β-Estradiol, ≥98%,
Species
human, mouse, rat

Proteins

Product Number
Description
Species
Estrogen Receptor-α human, ≥80% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution,
Species
human
PrEST Antigen ESR1, Prestige Antigens Powered by Atlas Antibodies, buffered aqueous solution,
Species
human
PrEST Antigen ESR1, Prestige Antigens Powered by Atlas Antibodies, buffered aqueous solution,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human ESR1,
Species
human