MilliporeSigma

GRIA2

glutamate receptor, ionotropic, AMPA 2

Synonyms:
GLUR2, GLURB, GluA2, GluR-K2, HBGR2
Species:
UniProtKB ID:
Gene ID:
  • Human(2891) Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(14800) glutamate receptor, ionotropic, AMPA2 (alpha 2)
  • Rat(29627) glutamate receptor, ionotropic, AMPA 2
  • chicken(414894) glutamate receptor, ionotropic, AMPA 2
  • cow(614283) glutamate receptor, ionotropic, AMPA 2
  • naked mole-rat(101708417) glutamate receptor, ionotropic, AMPA 2
  • domestic guinea pig(100379153) glutamate receptor, ionotropic, AMPA2 (alpha 2)
  • sheep(443272) glutamate receptor, ionotropic, AMPA 2
  • Horse(100069331) glutamate receptor, ionotropic, AMPA 2
  • domestic cat(101088234) glutamate receptor, ionotropic, AMPA 2
  • dog(482667) glutamate receptor, ionotropic, AMPA 2

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Small Molecule - Agonist

Product Number
Description
Species
2,6-Difluoro-4-[2-(phenylsul­fonyl­amino)­ethyl­thio]­phenoxy­acet­amide, ≥98% (HPLC), solid,
Species
human
Cyclothiazide, ,
Species
human, rat
(±)-AMPA, solid,
Species
rat
Kainic acid monohydrate, ≥99% (TLC),
Species
human, mouse, rat
(Aminomethyl)phosphonic acid, 99%,
Species
rat, human

Small Molecule - Allosteric Modulator

Product Number
Description
Species
CX546, ≥98% (HPLC), solid,
Species
human
Piracetam, ,
Species
human, rat
Cyclothiazide, ,
Species
human, rat
Kainic acid monohydrate, ≥99% (TLC),
Species
human, mouse, rat
Topiramate, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
GYKI 52466 hydrochloride, solid,
Species
human
Piracetam, ,
Species
human, rat
NBQX disodium salt hydrate, ≥98% (HPLC),
Species
human
CNQX disodium salt hydrate, ≥98% (HPLC), solid,
Species
human
DNQX, ≥98% (TLC),
Species
mouse, rat, human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Glutamate Receptor 2 & 3 Antibody, Chemicon®, from rabbit,
Species Reactivity
gerbil, guinea pig, hamster, human, monkey, mouse, rat
Application
immunocytochemistry
immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-GluR2/GRIA2 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-GRIA2 (AB1) antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
bovine, guinea pig, horse, human, mouse, rabbit, rat
Application
immunohistochemistry
western blot
Anti-GLUR2 pS880 (Clone 022.19.5) Antibody, clone 022.19.5, from mouse,
Species Reactivity
rat
Application
western blot
Anti-GluR2 Antibody, clone L21/32, clone L21/32, from mouse,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot

Small Molecule - Blocker

Product Number
Description
Species
Cyclothiazide, ,
Species
human, rat
Topiramate, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Topiramate, United States Pharmacopeia (USP) Reference Standard,
Species
human
Topiramate, European Pharmacopoeia (EP) Reference Standard,
Species
human
Topiramate solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
Cyclothiazide, ,
Species
human, rat
(±)-AMPA, solid,
Species
rat
Kainic acid monohydrate, ≥99% (TLC),
Species
human, mouse, rat
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Species
rat, human
L-Glutamic acid, BioUltra, ≥99.5% (NT),
Species
rat, human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human GRIA2 (1),
Species
human
MISSION® esiRNA, targeting human GRIA2 (2),
Species
human