MilliporeSigma

GRIA4

glutamate receptor, ionotropic, AMPA 4

Synonyms:
GLUR4, GLUR4C, GLURD, GluA4
Species:
UniProtKB ID:
Gene ID:
  • Human(2893) Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008]
  • Mouse(14802) glutamate receptor, ionotropic, AMPA4 (alpha 4)
  • Rat(29629) glutamate receptor, ionotropic, AMPA 4
  • sheep(443274) glutamate receptor, ionotropic, AMPA 4
  • domestic cat(101087003) glutamate receptor, ionotropic, AMPA 4
  • chicken(396137) glutamate receptor, ionotropic, AMPA 4
  • domestic guinea pig(100728256) glutamate receptor, ionotropic, AMPA 4
  • cow(529904) glutamate receptor, ionotrophic, AMPA 4
  • Horse(100061561) glutamate receptor, ionotropic, AMPA 4
  • dog(489427) glutamate receptor, ionotropic, AMPA 4
  • naked mole-rat(101698538) glutamate receptor, ionotropic, AMPA 4

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Small Molecule - Agonist

Product Number
Description
Species
2,6-Difluoro-4-[2-(phenylsul­fonyl­amino)­ethyl­thio]­phenoxy­acet­amide, ≥98% (HPLC), solid,
Species
human
Cyclothiazide, ,
Species
human, rat
(±)-AMPA, solid,
Species
rat
Kainic acid monohydrate, ≥99% (TLC),
Species
human, mouse, rat
(Aminomethyl)phosphonic acid, 99%,
Species
rat, human

Small Molecule - Allosteric Modulator

Product Number
Description
Species
CX546, ≥98% (HPLC), solid,
Species
human
Piracetam, ,
Species
human, rat
Cyclothiazide, ,
Species
human, rat
Kainic acid monohydrate, ≥99% (TLC),
Species
human, mouse, rat
Topiramate, United States Pharmacopeia (USP) Reference Standard,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
GYKI 52466 hydrochloride, solid,
Species
human
Piracetam, ,
Species
human, rat
NBQX disodium salt hydrate, ≥98% (HPLC),
Species
human
CNQX disodium salt hydrate, ≥98% (HPLC), solid,
Species
human
(±)-AMPA, solid,
Species
rat

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-GLUR4 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
Anti-GluR4/GluA4/GRIA4 Antibody, clone 4M5D0, Rabbit Monoclonal, ,
Species Reactivity
mouse, rat
Application
western blot
Anti-Glutamate Receptor 4 Antibody, Chemicon®, from rabbit,
Species Reactivity
mouse, rat
Application
immunocytochemistry
immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-GRIA4 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
bovine, human, mouse, rat
Application
ELISA
immunohistochemistry

western blot

Small Molecule - Blocker

Product Number
Description
Species
Cyclothiazide, ,
Species
human, rat
Kynurenic acid, ≥98%,
Species
rat, human
Topiramate, United States Pharmacopeia (USP) Reference Standard,
Species
human
Topiramate, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Topiramate, European Pharmacopoeia (EP) Reference Standard,
Species
human

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
Cyclothiazide, ,
Species
human, rat
(±)-AMPA, solid,
Species
rat
Kainic acid monohydrate, ≥99% (TLC),
Species
human, mouse, rat
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Species
rat, human
L-Glutamic acid, FCC,
Species
rat, human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Gria4,
Species
mouse
MISSION® esiRNA, targeting human GRIA4,
Species
human