MilliporeSigma

GRIN2B

glutamate receptor, ionotropic, N-methyl D-aspartate 2B

Synonyms:
GluN2B, MRD6, NMDAR2B, NR2B, hNR3
Species:
UniProtKB ID:
Gene ID:
  • Human(2904) Summary: N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]
  • Mouse(14812) glutamate receptor, ionotropic, NMDA2B (epsilon 2)
  • Rat(24410) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • cow(537804) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • dog(494009) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • chicken(417965) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • naked mole-rat(101723091) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • domestic guinea pig(100731840) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • Horse(100063746) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • domestic cat(101094356) glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • sheep(101118179) glutamate receptor, ionotropic, N-methyl D-aspartate 2B

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Small Molecule - Agonist

Product Number
Description
Species
Reversin 205, ≥98% (HPLC), film,
Species
mouse, rat, human
D-Cycloserine, synthetic,
Species
human
N-Methyl-D-aspartic acid, ≥98% (TLC), solid,
Species
human, rat
Dextromethorphan hydrobromide monohydrate, ≥99% (TLC),
Species
human
(S)-AMPA, ≥98%,
Species
mouse, human, rat

Small Molecule - Allosteric Modulator

Product Number
Description
Species
Ketamine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
(±)-Ketamine hydrochloride, solid,
Species
human
S-(+)-Ketamine hydrochloride, ,
Species
human
Ketamine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Species
human
Acamprosate calcium, ≥98% (HPLC), powder,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
DL-2-Aminoadipic acid, ≥99%,
Species
rat
Ro 8-4304, solid,
Species
human
2-Phenylquinoline, 99%,
Species
rat
Ro 25-6981 hydrochloride hydrate, ≥98% (HPLC), powder,
Species
human
CP-101,606, ≥98% (HPLC),
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-GRIN2B antibody produced in mouse, clone 2G5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
proximity ligation assay

western blot
Anti-phospho-GRIN2B (pSer1303) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
Anti-GRIN2B (Ab-1474) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
Anti-phospho-GRIN2B (pTyr1474) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
Anti-NMDANR2B antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
western blot

Small Molecule - Blocker

Product Number
Description
Species
N-(3,3-Diphenylpropyl)glycinamide, >98% (HPLC), solid,
Species
human
Agmatine sulfate salt, ≥97%, powder,
Species
human
Orphenadrine hydrochloride, ≥98.0% (AT),
Species
human
Orphenadrine for peak identification, European Pharmacopoeia (EP) Reference Standard,
Species
human
Orphenadrine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Species
human

Small Molecule - Inhibitor

Product Number
Description
Species
Pentamidine isethionate salt, powder,
Species
human
Orphenadrine hydrochloride, ≥98.0% (AT),
Species
human
Orphenadrine for peak identification, European Pharmacopoeia (EP) Reference Standard,
Species
human
Orphenadrine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Species
human
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Species
rat, human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human GRIN2B,
Species
human
MISSION® esiRNA, targeting mouse Grin2b,
Species
mouse