MilliporeSigma

GRM3

glutamate receptor, metabotropic 3

Synonyms:
GLUR3, GPRC1C, MGLUR3, mGlu3
Species:
UniProtKB ID:
Gene ID:
  • Human(2913) Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]
  • Mouse(108069) glutamate receptor, metabotropic 3
  • Rat(24416) glutamate receptor, metabotropic 3
  • domestic guinea pig(100731837) glutamate receptor, metabotropic 3
  • naked mole-rat(101713039) glutamate receptor, metabotropic 3
  • Zebrafish(565256) glutamate receptor, metabotropic 3
  • sheep(101113057) glutamate receptor, metabotropic 3
  • dog(100683236) glutamate receptor, metabotropic 3
  • Horse(100049918) glutamate receptor, metabotropic 3
  • domestic cat(101095810) glutamate receptor, metabotropic 3
  • cow(541056) glutamate receptor, metabotropic 3
  • chicken(418644) glutamate receptor, metabotropic 3

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Small Molecule - Agonist

Product Number
Description
Species
trans-(±)-ACPD monohydrate, solid, ≥97% (NMR),
Species
human
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Species
rat, human
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Species
rat, human
L-Glutamic acid, FCC,
Species
rat, human
L-Glutamic acid, BioUltra, ≥99.5% (NT),
Species
rat, human

Small Molecule - Antagonist

Product Number
Description
Species
(±)-α-Methyl-(4-carboxyphenyl)glycine, ,
Species
human, rat
DL-2-Amino-3-phosphonopropionic acid, ,
Species
human
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Species
rat, human
L-Glutamic acid, FCC,
Species
rat, human
L-Glutamic acid, BioUltra, ≥99.5% (NT),
Species
rat, human

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
(±)-α-Methyl-(4-carboxyphenyl)glycine, ,
Species
human, rat
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Species
rat, human
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Species
rat, human
L-Glutamic acid, FCC,
Species
rat, human
L-Glutamic acid, BioUltra, ≥99.5% (NT),
Species
rat, human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human GRM3,
Species
human