MilliporeSigma

GRM4

glutamate receptor, metabotropic 4

Synonyms:
GPRC1D, MGLUR4, mGlu4
Species:
UniProtKB ID:
Gene ID:
  • Human(2914) Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
  • Mouse(268934) glutamate receptor, metabotropic 4
  • Rat(24417) glutamate receptor, metabotropic 4
  • domestic guinea pig(100727790) glutamate receptor, metabotropic 4
  • naked mole-rat(101704191) glutamate receptor, metabotropic 4
  • Zebrafish(567181) glutamate receptor, metabotropic 4
  • sheep(101119427) glutamate receptor, metabotropic 4
  • dog(481749) glutamate receptor, metabotropic 4
  • domestic cat(101094419) glutamate receptor, metabotropic 4
  • cow(790333) glutamate receptor, metabotropic 4
  • chicken(419906) glutamate receptor, metabotropic 4

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Small Molecule - Agonist

Product Number
Description
Species
O-Phospho-L-serine, ,
Species
human
Quisqualic acid, powder,
Species
rat
trans-(±)-ACPD monohydrate, solid, ≥97% (NMR),
Species
human
L-2-Aminoadipic acid, ≥98% (TLC),
Species
rat, human
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Species
rat, human

Small Molecule - Antagonist

Product Number
Description
Species
Quisqualic acid, powder,
Species
rat
DL-2-Amino-3-phosphonopropionic acid, ,
Species
human
(±)-AMPA, solid,
Species
rat
(Aminomethyl)phosphonic acid, 99%,
Species
rat, human
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Species
rat, human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-MGLUR4 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot
Anti-GRM4 / MGLUR4 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, monkey, mouse, pig, rabbit
Application
immunohistochemistry
western blot
Anti-mGluR4 Antibody, from rabbit,
Species Reactivity
mouse, rat
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Quisqualic acid, powder,
Species
rat
L-2-Aminoadipic acid, ≥98% (TLC),
Species
rat, human
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Species
rat, human
(Aminomethyl)phosphonic acid, 99%,
Species
rat, human
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Species
rat, human

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Species
rat, human
(±)-AMPA, solid,
Species
rat
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Species
rat, human
L-Glutamic acid, FCC,
Species
rat, human
L-Glutamic acid, BioUltra, ≥99.5% (NT),
Species
rat, human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human GRM4,
Species
human
MISSION® esiRNA, targeting mouse Grm4,
Species
mouse