MilliporeSigma

GRM5

glutamate receptor, metabotropic 5

Synonyms:
GPRC1E, MGLUR5, mGlu5
Species:
UniProtKB ID:
Gene ID:
  • Human(2915) Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
  • Mouse(108071) glutamate receptor, metabotropic 5
  • Rat(24418) glutamate receptor, metabotropic 5
  • domestic guinea pig(100714109) glutamate receptor, metabotropic 5
  • naked mole-rat(101696979) glutamate receptor, metabotropic 5
  • chicken(373933) glutamate receptor, metabotropic 5
  • domestic cat(101091895) glutamate receptor, metabotropic 5
  • cow(100336861) glutamate receptor, metabotropic 5
  • dog(485146) glutamate receptor, metabotropic 5

Custom & Knockdown Gene Products

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Small Molecule - Agonist

Product Number
Description
Species
Quisqualic acid, powder,
Species
rat
L-2-Aminoadipic acid, ≥98% (TLC),
Species
rat, human
trans-(±)-ACPD monohydrate, solid, ≥97% (NMR),
Species
human
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Species
rat, human
(±)-AMPA, solid,
Species
rat

Small Molecule - Antagonist

Product Number
Description
Species
SIB 1757, ≥99% (HPLC), crystalline,
Species
human
SIB 1893, >99%, solid,
Species
human
6-Methyl-2-(phenylethynyl)pyridine hydrochloride, ≥98% (HPLC),
Species
rat, human
(±)-α-Methyl-(4-carboxyphenyl)glycine, ,
Species
human, rat
Quisqualic acid, powder,
Species
rat

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-GRM5 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

western blot
Monoclonal Anti-Mglur1/5 antibody produced in mouse, clone S75-33, purified immunoglobulin,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
immunoprecipitation (IP)

western blot
Monoclonal Anti-Mglur1/5 - Atto 488 antibody produced in mouse, clone S75-33, purified immunoglobulin,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
immunoprecipitation (IP)

western blot
Monoclonal Anti-Mglur1/5 - Percp antibody produced in mouse, clone S75-33, purified immunoglobulin,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
immunoprecipitation (IP)

western blot
Monoclonal Anti-Mglur1/5 - Atto 390 antibody produced in mouse, clone S75-33, purified immunoglobulin,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
immunoprecipitation (IP)

western blot

Proteins

Product Number
Description
Species
Metabotropic Glutamate Receptor 5, control peptide for AB5675, ,
Species
rat

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Grm5,
Species
mouse
MISSION® esiRNA, targeting human GRM5,
Species
human