MilliporeSigma

GRM7

glutamate receptor, metabotropic 7

Synonyms:
GLUR7, GPRC1G, MGLU7, MGLUR7
Species:
UniProtKB ID:
Gene ID:
  • Human(2917) Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
  • Mouse(108073) glutamate receptor, metabotropic 7
  • Rat(81672) glutamate receptor, metabotropic 7
  • Zebrafish(564461) glutamate receptor, metabotropic 7
  • chicken(416112) glutamate receptor, metabotropic 7
  • Horse(100052696) glutamate receptor, metabotropic 7
  • domestic cat(101090088) glutamate receptor, metabotropic 7
  • Domestic Rabbit(100343810) glutamate receptor, metabotropic 7
  • cow(535362) glutamate receptor, metabotropic 7
  • dog(484674) glutamate receptor, metabotropic 7

Custom & Knockdown Gene Products

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Small Molecule - Agonist

Product Number
Description
Species
O-Phospho-L-serine, ,
Species
human
trans-(±)-ACPD monohydrate, solid, ≥97% (NMR),
Species
human
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Species
rat, human
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Species
rat, human
L-Glutamic acid, FCC,
Species
rat, human

Small Molecule - Antagonist

Product Number
Description
Species
DL-2-Amino-3-phosphonopropionic acid, ,
Species
human
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Species
rat, human
L-Glutamic acid, FCC,
Species
rat, human
L-Glutamic acid, BioUltra, ≥99.5% (NT),
Species
rat, human
L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
Species
rat, human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-GRM7 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

western blot
Monoclonal Anti-GRM7 antibody produced in mouse, clone 1H5, ascites fluid,
Species Reactivity
human
Application
ELISA
western blot
Anti-Metabotropic Glutamate Receptor 7 Antibody, Chemicon®, from rabbit,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-MGLUR7 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot
Anti-mGluR7 Antibody, Upstate®, from rabbit,
Species Reactivity
rat
Application
western blot

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Species
rat, human
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Species
rat, human
L-Glutamic acid, FCC,
Species
rat, human
L-Glutamic acid, BioUltra, ≥99.5% (NT),
Species
rat, human
L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
Species
rat, human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Ak032068,
Species
mouse
MISSION® esiRNA, targeting human GRM7,
Species
human