MilliporeSigma

KCNA1

potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)

Synonyms:
AEMK, EA1, HBK1, HUK1, KV1.1, MBK1, MK1, RBK1
Species:
UniProtKB ID:
Gene ID:
  • Human(3736) Summary: This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). [provided by RefSeq, Jul 2008]
  • Mouse(16485) potassium voltage-gated channel, shaker-related subfamily, member 1
  • Rat(24520) potassium voltage-gated channel, shaker-related subfamily, member 1
  • cow(538703) potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
  • domestic cat(101093364) potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
  • Horse(100051648) potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
  • dog(486732) potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
  • Zebrafish(327087) potassium voltage-gated channel, shaker-related subfamily, member 1
  • chicken(428101) potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
  • domestic guinea pig(100731979) potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
  • Domestic Rabbit(100037722) potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
  • Domestic Rabbit(100037717) potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)

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Small Molecule - Allosteric Modulator

Product Number
Description
Species
Cromakalim, ,
Species
rat
Diazoxide, ,
Species
rat, mouse, human
4-Aminopyridine, ≥99%,
Species
rat, human, mouse
4-Aminopyridine, 98%,
Species
rat, human, mouse

Small Molecule - Antagonist

Product Number
Description
Species
Cromakalim, ,
Species
rat
Pinacidil monohydrate, powder,
Species
mouse, rat, human
Diazoxide, ,
Species
rat, mouse, human

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-KCNA1 antibody produced in mouse, clone S36-15, 1 mg/mL, purified immunoglobulin,
Species Reactivity
mouse, rat
Application
immunocytochemistry
western blot
Monoclonal Anti-KCNA1 antibody produced in mouse, clone S20-78, 1 mg/mL, purified immunoglobulin,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
immunoprecipitation (IP)

western blot
Anti-KCNA1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Monoclonal Anti-KCNA1, (C-terminal) antibody produced in mouse, clone 2D8, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Anti-Potassium Channel Kv1.1 Antibody, clone K36/15, clone K36/15, from mouse,
Species Reactivity
mouse, rat
Application
immunofluorescence
immunohistochemistry

western blot

Small Molecule - Blocker

Product Number
Description
Species
Guanidine hydrochloride, BioUltra, for molecular biology, ≥99.5% (AT),
Species
human
Guanidine hydrochloride, anhydrous, free-flowing, Redi-Dri, ≥99%,
Species
human
Guanidine hydrochloride, ,
Species
human
Guanidine hydrochloride, ≥99.0% (AT),
Species
human
Guanidine hydrochloride, ≥99% (titration), organic base and chaeotropic agent,
Species
human

Small Molecule - Inhibitor

Product Number
Description
Species
Pinacidil monohydrate, powder,
Species
mouse, rat, human
Diazoxide, ,
Species
rat, mouse, human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Kcna1,
Species
mouse
MISSION® esiRNA, targeting human KCNA1,
Species
human