MilliporeSigma

KCNA2

potassium voltage-gated channel, shaker-related subfamily, member 2

Synonyms:
HBK5, HK4, HUKIV, KV1.2, MK2, NGK1, RBK2
Species:
UniProtKB ID:
Gene ID:
  • Human(3737) Summary: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. [provided by RefSeq, Jul 2008]
  • Mouse(16490) potassium voltage-gated channel, shaker-related subfamily, member 2
  • Rat(25468) potassium voltage-gated channel, shaker-related subfamily, member 2
  • cow(539608) potassium voltage-gated channel, shaker-related subfamily, member 2
  • domestic cat(101083868) potassium voltage-gated channel, shaker-related subfamily, member 2
  • dog(404022) potassium voltage-gated channel, shaker-related subfamily, member 2
  • Zebrafish(100537815) potassium voltage-gated channel, shaker-related subfamily, member 2
  • chicken(395117) potassium voltage-gated channel, shaker-related subfamily, member 2
  • naked mole-rat(101717332) potassium voltage-gated channel, shaker-related subfamily, member 2
  • domestic guinea pig(100735605) potassium voltage-gated channel, shaker-related subfamily, member 2
  • sheep(101112012) potassium voltage-gated channel, shaker-related subfamily, member 2

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Potassium Channel Kv1.2 Antibody, clone K14/16, clone K14/16, from mouse,
Species Reactivity
rat
Application
immunofluorescence
immunohistochemistry

western blot
ANTI-KCNA2 (C-TERM) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Monoclonal Anti-KCNA2 antibody produced in mouse, clone S14-16, 1 mg/mL, purified immunoglobulin,
Species Reactivity
human, mouse, rat, zebrafish
Application
immunohistochemistry
immunoprecipitation (IP)

western blot

Small Molecule - Blocker

Product Number
Description
Species
Guanidine hydrochloride, BioUltra, for molecular biology, ≥99.5% (AT),
Species
human
Guanidine hydrochloride, anhydrous, free-flowing, Redi-Dri, ≥99%,
Species
human
Guanidine hydrochloride, ,
Species
human
Guanidine hydrochloride, ≥99.0% (AT),
Species
human
Guanidine hydrochloride, ≥99% (titration), organic base and chaeotropic agent,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Kcna2,
Species
mouse
MISSION® esiRNA, targeting human KCNA2,
Species
human