MilliporeSigma

KCNA5

potassium voltage-gated channel, shaker-related subfamily, member 5

Synonyms:
ATFB7, HCK1, HK2, HPCN1, KV1.5, PCN1
Species:
UniProtKB ID:
Gene ID:
  • Human(3741) Summary: Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7). [provided by RefSeq, May 2012]
  • Mouse(16493) potassium voltage-gated channel, shaker-related subfamily, member 5
  • Rat(25470) potassium voltage-gated channel, shaker-related subfamily, member 5
  • cow(508960) potassium voltage-gated channel, shaker-related subfamily, member 5
  • domestic cat(101100573) potassium voltage-gated channel, shaker-related subfamily, member 5
  • dog(403995) potassium voltage-gated channel, shaker-related subfamily, member 5
  • chicken(395115) potassium voltage-gated channel, shaker-related subfamily, member 5
  • naked mole-rat(101715453) potassium voltage-gated channel, shaker-related subfamily, member 5
  • domestic guinea pig(100732253) potassium voltage-gated channel, shaker-related subfamily, member 5
  • Domestic Rabbit(100008684) potassium voltage-gated channel, shaker-related subfamily, member 5
  • sheep(101111448) potassium voltage-gated channel, shaker-related subfamily, member 5

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-KCNA5 antibody produced in mouse, clone S7-45, 1 mg/mL, purified immunoglobulin,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
immunoprecipitation (IP)

western blot
Anti-KCNA5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-Potassium Channel Kv1.5 antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Species Reactivity
mouse, rat
Application
western blot

Small Molecule - Blocker

Product Number
Description
Species
Guanidine hydrochloride, anhydrous, free-flowing, Redi-Dri, ≥99%,
Species
human
Guanidine hydrochloride, ,
Species
human
Guanidine hydrochloride, ≥98%,
Species
human
Dalfampridine, United States Pharmacopeia (USP) Reference Standard,
Species
human
Guanidine hydrochloride, ≥99.0% (AT),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human KCNA5,
Species
human