MilliporeSigma

KCNH2

potassium voltage-gated channel, subfamily H (eag-related), member 2

Synonyms:
ERG1, HERG, HERG1, Kv11.1, LQT2, SQT1
Species:
UniProtKB ID:
Gene ID:
  • Human(3757) Summary: This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
  • Mouse(16511) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • Rat(117018) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • Zebrafish(405763) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • naked mole-rat(101711977) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • domestic cat(101081621) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • Horse(100064000) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • Domestic Rabbit(100009242) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • dog(403761) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • domestic guinea pig(100135563) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • cow(539971) potassium voltage-gated channel, subfamily H (eag-related), member 2

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Small Molecule - Antagonist

Product Number
Description
Species
Sotalol hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Species
human
Sotalol hydrochloride, British Pharmacopoeia (BP) Reference Standard,
Species
human
Glyburide, meets USP testing specifications,
Species
rat, human
(±)-Sotalol hydrochloride, ≥98% (TLC), powder,
Species
human
Glybenclamide, ≥99% (HPLC),
Species
rat, human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Potassium Channel ERG1 Antibody, CT, Chemicon®, from rabbit,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-Potassium Channel HERG Antibody, CT, Chemicon®, from rabbit,
Species Reactivity
human
Application
immunocytochemistry
immunoprecipitation (IP)

western blot
Anti-KCNH2 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
Anti-Potassium Channel Kv11.1 (HERG) Extracellular−FITC antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Species Reactivity
human
Application
flow cytometry
immunocytochemistry
Anti-Potassium Channel hKv11.1 antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Species Reactivity
human
Application
western blot

Small Molecule - Blocker

Product Number
Description
Species
Amiodarone hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Dofetilide, United States Pharmacopeia (USP) Reference Standard,
Species
human
Ibutilide fumarate, United States Pharmacopeia (USP) Reference Standard, monograph mol wt. 885.23 ([(C20H36N2O3S)2 . C4H4O4]),
Species
human
Ibutilide hemifumarate salt, ≥98% (HPLC),
Species
human
Sotalol hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Species
human

Small Molecule - Inhibitor

Product Number
Description
Species
Loratadine, ≥98% (HPLC), powder,
Species
rat, human
Terfenadine, ,
Species
mouse, rat, human
Cocaine free base, ,
Species
mouse, rat, human
Pimozide, ,
Species
human, mouse, rat
Haloperidol, powder,
Species
human, rat

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human KCNH2,
Species
human