MilliporeSigma

KCNQ2

potassium voltage-gated channel, KQT-like subfamily, member 2

Synonyms:
BFNC, BFNS1, EBN, EBN1, EIEE7, ENB1, HNSPC, KCNA11, KV7.2, KVEBN1
Species:
UniProtKB ID:
Gene ID:
  • Human(3785) Summary: The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(16536) potassium voltage-gated channel, subfamily Q, member 2
  • Rat(170848) potassium voltage-gated channel, KQT-like subfamily, member 2
  • chicken(428151) potassium voltage-gated channel, KQT-like subfamily, member 2
  • naked mole-rat(101715997) potassium voltage-gated channel, KQT-like subfamily, member 2
  • domestic guinea pig(100732168) potassium voltage-gated channel, KQT-like subfamily, member 2
  • sheep(101118630) potassium voltage-gated channel, KQT-like subfamily, member 2
  • domestic cat(101101044) potassium voltage-gated channel, KQT-like subfamily, member 2
  • Horse(100146986) potassium voltage-gated channel, KQT-like subfamily, member 2
  • cow(505963) potassium voltage-gated channel, KQT-like subfamily, member 2
  • dog(612515) potassium voltage-gated channel, KQT-like subfamily, member 2
  • Zebrafish(100537363) potassium voltage-gated channel, KQT-like subfamily, member 2

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Small Molecule - Activator

Product Number
Description
Species
BMS 204352, ≥98% (HPLC),
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-KCNQ2 (AB2) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rat
Application
immunohistochemistry
western blot
Anti-KCNQ2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
Anti-KCNQ2 antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rat
Application
immunohistochemistry
western blot
Anti-KCNQ2 (AB1) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rat
Application
western blot

Small Molecule - Blocker

Product Number
Description
Species
Retigabine, ≥98% (HPLC),
Species
human
Retigabine, analytical standard,
Species
human
Guanidine hydrochloride, BioUltra, for molecular biology, ≥99.5% (AT),
Species
human
Guanidine hydrochloride, anhydrous, free-flowing, Redi-Dri, ≥99%,
Species
human
Guanidine hydrochloride, ,
Species
human

Small Molecule - Inhibitor

Product Number
Description
Species
N-Ethylmaleimide, crystalline, ≥98% (HPLC),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human KCNQ2,
Species
human