MilliporeSigma

KCNQ3

potassium voltage-gated channel, KQT-like subfamily, member 3

Synonyms:
BFNC2, EBN2, KV7.3
Species:
UniProtKB ID:
Gene ID:
  • Human(3786) Summary: The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Two variants encoding distinct isoforms have been found. [provided by RefSeq, Mar 2011]
  • Mouse(110862) potassium voltage-gated channel, subfamily Q, member 3
  • Rat(29682) potassium voltage-gated channel, KQT-like subfamily, member 3
  • chicken(420325) potassium voltage-gated channel, KQT-like subfamily, member 3
  • naked mole-rat(101726081) potassium voltage-gated channel, KQT-like subfamily, member 3
  • domestic guinea pig(100722068) potassium voltage-gated channel, KQT-like subfamily, member 3
  • sheep(101120673) potassium voltage-gated channel, KQT-like subfamily, member 3
  • domestic cat(101093496) potassium voltage-gated channel, KQT-like subfamily, member 3
  • Horse(100057886) potassium voltage-gated channel, KQT-like subfamily, member 3
  • cow(281884) potassium voltage-gated channel, KQT-like subfamily, member 3
  • dog(475103) potassium voltage-gated channel, KQT-like subfamily, member 3
  • Zebrafish(799747) potassium voltage-gated channel, KQT-like subfamily, member 3

Custom & Knockdown Gene Products

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Small Molecule - Activator

Product Number
Description
Species
BMS 204352, ≥98% (HPLC),
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-KCNQ3 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
western blot

Small Molecule - Blocker

Product Number
Description
Species
Retigabine, ≥98% (HPLC),
Species
human
Retigabine, analytical standard,
Species
human
Guanidine hydrochloride, anhydrous, free-flowing, Redi-Dri, ≥99%,
Species
human
Guanidine hydrochloride, ,
Species
human
Guanidine hydrochloride, ≥98%,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human KCNQ3,
Species
human