MilliporeSigma

KCNQ4

potassium voltage-gated channel, KQT-like subfamily, member 4

Synonyms:
DFNA2, DFNA2A, KV7.4
Species:
UniProtKB ID:
Gene ID:
  • Human(9132) Summary: The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(60613) potassium voltage-gated channel, subfamily Q, member 4
  • Rat(298496) potassium voltage-gated channel, KQT-like subfamily, member 4
  • chicken(419643) potassium voltage-gated channel, KQT-like subfamily, member 4
  • naked mole-rat(101714294) potassium voltage-gated channel, KQT-like subfamily, member 4
  • domestic guinea pig(100716024) potassium voltage-gated channel, KQT-like subfamily, member 4
  • sheep(101122655) potassium voltage-gated channel, KQT-like subfamily, member 4
  • Domestic Rabbit(100358271) potassium voltage-gated channel, KQT-like subfamily, member 4
  • domestic cat(101091641) potassium voltage-gated channel, KQT-like subfamily, member 4
  • Horse(100067963) potassium voltage-gated channel, KQT-like subfamily, member 4
  • cow(528741) potassium voltage-gated channel, KQT-like subfamily, member 4
  • dog(482451) potassium voltage-gated channel, KQT-like subfamily, member 4

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Small Molecule - Activator

Product Number
Description
Species
BMS 204352, ≥98% (HPLC),
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-KCNQ4 antibody produced in mouse, clone 2H6, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
mouse
Application
ELISA
western blot
Anti-KCNQ4 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot

Small Molecule - Blocker

Product Number
Description
Species
Retigabine, analytical standard,
Species
human
Retigabine, ≥98% (HPLC),
Species
human
Guanidine hydrochloride, BioUltra, for molecular biology, ≥99.5% (AT),
Species
human
Guanidine hydrochloride, anhydrous, free-flowing, Redi-Dri, ≥99%,
Species
human
Guanidine hydrochloride, ,
Species
human

Small Molecule - Inhibitor

Product Number
Description
Species
N-Ethylmaleimide, crystalline, ≥98% (HPLC),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human KCNQ4,
Species
human
MISSION® esiRNA, targeting mouse Kcnq4,
Species
mouse