MilliporeSigma

NOS1

nitric oxide synthase 1 (neuronal)

Synonyms:
IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS
Species:
UniProtKB ID:
Gene ID:
  • Human(4842) Summary: The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]
  • Mouse(18125) nitric oxide synthase 1, neuronal
  • Rat(24598) nitric oxide synthase 1, neuronal
  • Domestic Rabbit(100009243) nitric oxide synthase 1 (neuronal)
  • naked mole-rat(101711993) nitric oxide synthase 1 (neuronal)
  • cow(536132) nitric oxide synthase 1 (neuronal)
  • domestic cat(101100342) nitric oxide synthase 1 (neuronal)
  • Zebrafish(60658) nitric oxide synthase 1 (neuronal)
  • Horse(100051079) nitric oxide synthase 1 (neuronal)
  • dog(477498) nitric oxide synthase 1 (neuronal)
  • chicken(427721) nitric oxide synthase 1 (neuronal)
  • domestic guinea pig(100729682) nitric oxide synthase 1 (neuronal)

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Small Molecule - Antagonist

Product Number
Description
Species
(−)-Thalidomide, >98%, solid,
Species
human, mouse, rat
(+)-Thalidomide, ≥98% (HPLC), powder,
Species
human, mouse, rat
Ammonium pyrrolidinedithiocarbamate, ~99%,
Species
human
Nω-Nitro-L-arginine, ≥98% (TLC),
Species
rat, mouse, human
(±)-Thalidomide, ≥98%, powder,
Species
human, mouse, rat

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-NOS1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
Monoclonal Anti-Nitrotyrosine antibody produced in mouse, clone 39B6, 1 mg/mL, purified immunoglobulin,
Species Reactivity
dog, human, mouse, rat
Application
ELISA
immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-Nitrotyrosine Antibody Alexa Fluor 488 Conjugate, from rabbit, ALEXA FLUOR 488,
Species Reactivity
all, human
Application
immunocytochemistry
Anti-Nitric Oxide Synthase I Antibody, serum, Chemicon®,
Species Reactivity
human, monkey, mouse, rat, sheep
Application
immunohistochemistry
western blot
Anti-Nitrotyrosine Antibody, clone 2A8.2, clone 2A8.2, Chemicon®, from mouse,
Species Reactivity
all
Application
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Spermidine trihydrochloride, ≥98% (TLC),
Species
human
4-Nitrocatechol, ≥96.0%,
Species
rat
5-Methyl-2-nitroaniline, 95%,
Species
rat
2,6-Di-tert-butyl-4-methylphenol, purum, ≥99.0% (GC),
Species
rat, human
L-Arginine, ,
Species
rat, human

Kits

Product Number
Description
Species
Nitric Oxide Synthase Detection System, Fluorimetric, sufficient for 200 reactions,
Species
human

Small Molecule - Precursor

Product Number
Description
Species
L-Arginine, ,
Species
rat, human
L-Arginine, BioUltra, ≥99.5% (NT),
Species
rat, human
L-Arginine, reagent grade, ≥98%,
Species
rat, human
L-Arginine, from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%,
Species
rat, human
L-Arginine, 99%, FCC, FG,
Species
rat, human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Nos1,
Species
mouse