MilliporeSigma

PPM1A

protein phosphatase, Mg2+/Mn2+ dependent, 1A

Synonyms:
PP2C-ALPHA, PP2CA, PP2Calpha
Species:
UniProtKB ID:
Gene ID:
  • Human(5494) Summary: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
  • Mouse(19042) protein phosphatase 1A, magnesium dependent, alpha isoform
  • Rat(24666) protein phosphatase, Mg2+/Mn2+ dependent, 1A
  • Domestic Rabbit(100009431) protein phosphatase, Mg2+/Mn2+ dependent, 1A
  • domestic cat(101101571) protein phosphatase, Mg2+/Mn2+ dependent, 1A
  • naked mole-rat(101720711) protein phosphatase, Mg2+/Mn2+ dependent, 1A
  • sheep(101103650) protein phosphatase, Mg2+/Mn2+ dependent, 1A
  • domestic guinea pig(100734826) protein phosphatase, Mg2+/Mn2+ dependent, 1A
  • cow(281994) protein phosphatase, Mg2+/Mn2+ dependent, 1A
  • dog(480344) protein phosphatase, Mg2+/Mn2+ dependent, 1A
  • chicken(423525) protein phosphatase, Mg2+/Mn2+ dependent, 1A

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-PPM1A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

western blot
Anti-PPM1A, clone 7F12 Antibody, clone 7F12, from mouse,
Species Reactivity
human
Application
ELISA
flow cytometry

western blot
Anti-PPM1A antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Hexamethylenediamine, technical grade, 70%,
Species
rat
Hexamethylenediamine, 98%,
Species
rat
Taurine, ,
Species
rat
Taurine, BioUltra, ≥99.5% (T),
Species
rat
Spermidine, BioReagent, for molecular biology, suitable for cell culture, ≥98%,
Species
rat

Proteins

Product Number
Description
Species
PP2C α human, recombinant, expressed in E. coli, ≥95% (SDS-PAGE),
Species
human
PP2C-α, active, GST tagged human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human PPM1A,
Species
human
MISSION® esiRNA, targeting mouse Ppm1a,
Species
mouse