MilliporeSigma

PTGER4

prostaglandin E receptor 4 (subtype EP4)

Synonyms:
EP4, EP4R
Species:
UniProtKB ID:
Gene ID:
  • Human(5734) Summary: The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]
  • Mouse(19219) prostaglandin E receptor 4 (subtype EP4)
  • Rat(84023) prostaglandin E receptor 4 (subtype EP4)
  • sheep(101104343) prostaglandin E receptor 4 (subtype EP4)
  • domestic cat(100169968) prostaglandin E receptor 4 (subtype EP4)
  • naked mole-rat(101723705) prostaglandin E receptor 4 (subtype EP4)
  • domestic cat(101094734) prostaglandin E receptor 4 (subtype EP4)
  • domestic guinea pig(100192398) prostaglandin E receptor 4 (subtype EP4)
  • Domestic Rabbit(100009081) prostaglandin E receptor 4 (subtype EP4)
  • dog(403589) prostaglandin E receptor 4 (subtype EP4)
  • chicken(427183) prostaglandin E receptor 4 (subtype EP4)
  • sheep(443222) prostaglandin E receptor 4 (subtype EP4)
  • cow(282331) prostaglandin E receptor 4 (subtype EP4)

Custom & Knockdown Gene Products

  • siRNA

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  • Custom Gene Products

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Small Molecule - Agonist

Product Number
Description
Species
Dinoprostone, United States Pharmacopeia (USP) Reference Standard,
Species
human
Dinoprostone, European Pharmacopoeia (EP) Reference Standard,
Species
human
Prostaglandin E1, powder, γ-irradiated, BioXtra, suitable for cell culture,
Species
human, mouse
Prostaglandin E1, synthetic, powder, BioReagent, suitable for cell culture,
Species
human, mouse
Prostaglandin E1, ≥98% (HPLC), synthetic,
Species
human, mouse

Small Molecule - Antagonist

Product Number
Description
Species
Prostaglandin E1, powder, γ-irradiated, BioXtra, suitable for cell culture,
Species
human, mouse
Prostaglandin E1, synthetic, powder, BioReagent, suitable for cell culture,
Species
human, mouse
Prostaglandin E1, ≥98% (HPLC), synthetic,
Species
human, mouse
Prostaglandin E2, ≥93% (HPLC), synthetic,
Species
mouse, human
Prostaglandin E2, γ-irradiated, powder, BioXtra, suitable for cell culture,
Species
human, mouse

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-PE2R4 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
immunofluorescence

western blot
Anti-PTGER4 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-EP4 Prostaglandin Receptor antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
canine, human
Application
ELISA
western blot

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
Prostaglandin E2, ≥93% (HPLC), synthetic,
Species
mouse, human
Indomethacin, 98.5-100.5% (in accordance with EP),
Species
human, mouse, rat

Proteins

Product Number
Description
Species
ChemiScreen Membrane Preparation
Recombinant Human EP4 Prostanoid Receptor
, Human EP4 GPCR membrane preparation for Radioligand binding Assays & GTPγS binding.,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Ptger4,
Species
mouse
MISSION® esiRNA, targeting human PTGER4,
Species
human