MilliporeSigma

PTGS2

prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

Synonyms:
COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2
Species:
UniProtKB ID:
Gene ID:
  • Human(5743) Summary: Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]
  • Mouse(19225) prostaglandin-endoperoxide synthase 2
  • Rat(29527) prostaglandin-endoperoxide synthase 2
  • Goat(100860905) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • cow(282023) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • Horse(791253) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • domestic cat(100126581) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • dog(442942) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • Domestic Rabbit(100009248) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • sheep(443460) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • naked mole-rat(101704771) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • chicken(396451) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • domestic guinea pig(100135607) prostaglandin-endoperoxide synthase 2

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ELISA

Product Number
Description
Species
Human COX-2 ELISA Kit, for cell culture supernatants, plasma, and serum samples,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-PTGS2 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
COX-2 (SP21) Rabbit Monoclonal Antibody, ,
Species Reactivity
human
Application
immunohistochemistry
Anti-COX2/PTGS2 Antibody, clone 2V7G8, Rabbit Monoclonal, ,
Species Reactivity
mouse
Application
immunohistochemistry
western blot
Anti-Cyclooxygenase-2 Antibody, Chemicon®, from rabbit,
Species Reactivity
bovine, human, mouse, sheep
Application
ELISA
western blot
Anti-Cox2 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry

immunoprecipitation (IP)

western blot

Small Molecule - Blocker

Product Number
Description
Species
N-p-Tosyl-L-phenylalanine chloromethyl ketone, ≥97% (TLC), powder,
Species
human

Small Molecule - Inhibitor

Product Number
Description
Species
Etodolac, European Pharmacopoeia (EP) Reference Standard,
Species
human
Carprofen, VETRANAL®, analytical standard,
Species
human
Carprofen, ≥97% (HPLC),
Species
human
Aceclofenac for peak identification, European Pharmacopoeia (EP) Reference Standard,
Species
human
Nabumetone, European Pharmacopoeia (EP) Reference Standard,
Species
human

Proteins

Product Number
Description
Species
Cyclooxygenase 2 human, ≥70% (SDS-PAGE), recombinant, expressed in insect cells, aqueous solution, ≥8000 units/mg protein,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Ptgs2,
Species
mouse
MISSION® esiRNA, targeting human PTGS2,
Species
human