MilliporeSigma

RPE65

retinal pigment epithelium-specific protein 65kDa

Synonyms:
LCA2, RP20, mRPE65, rd12, sRPE65
Species:
UniProtKB ID:
Gene ID:
  • Human(6121) Summary: This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa. [provided by RefSeq, Jul 2008]
  • Mouse(19892) retinal pigment epithelium 65
  • Rat(89826) retinal pigment epithelium 65
  • naked mole-rat(101716560) retinal pigment epithelium-specific protein 65kDa
  • domestic guinea pig(100721944) retinal pigment epithelium-specific protein 65kDa
  • chicken(395700) retinal pigment epithelium-specific protein 65kDa
  • domestic cat(101090034) retinal pigment epithelium-specific protein 65kDa
  • Domestic Rabbit(100352270) retinal pigment epithelium-specific protein 65kDa
  • sheep(101116520) retinal pigment epithelium-specific protein 65kDa
  • cow(282043) retinal pigment epithelium-specific protein 65kDa
  • dog(403803) retinal pigment epithelium-specific protein 65kDa

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-RPE65 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
canine, human
Application
ELISA
western blot
Anti-Retinal Pigment Epithelium 65 Antibody, clone 401.8B11.3D9, Chemicon®, from mouse,
Species Reactivity
xenopus, bovine, human, mouse
Application
ELISA
immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-RPE65 Antibody, clone 2F8 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse, rabbit
Application
affinity binding assay
immunofluorescence

immunohistochemistry

western blot
Anti-RPE65 Antibody, clone 401.8B11.3D9 ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
xenopus, bovine, canine, human, monkey, mouse, porcine, rat
Application
immunofluorescence
immunohistochemistry

western blot
Anti-RPE65 Antibody, clone KPSA1, ,
Species Reactivity
bovine, human, mouse
Application
ELISA
immunohistochemistry

western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human RPE65,
Species
human
MISSION® esiRNA, targeting mouse Rpe65,
Species
mouse