MilliporeSigma

TNF

tumor necrosis factor

Synonyms:
DIF, TNF-alpha, TNFA, TNFSF2
Species:
UniProtKB ID:
Gene ID:
  • Human(7124) Summary: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]
  • Mouse(21926) tumor necrosis factor
  • Rat(24835) tumor necrosis factor
  • dog(403922) tumor necrosis factor
  • domestic cat(493755) tumor necrosis factor
  • Horse(100033834) tumor necrosis factor
  • Goat(100861232) tumor necrosis factor alpha
  • cow(280943) tumor necrosis factor
  • sheep(443540) tumor necrosis factor
  • Domestic Rabbit(100009088) tumor necrosis factor
  • domestic guinea pig(100135630) tumor necrosis factor
  • naked mole-rat(101718432) tumor necrosis factor

Custom & Knockdown Gene Products

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ELISA

Product Number
Description
Species
Rhesus Macaque TNFα / Tumor Necrosis Factor alpha ELISA Kit, ,
Species
Rat Tumor Necrosis Factor α ELISA Kit, for serum, plasma and cell culture supernatant,
Species
rat
Rat Tumor Necrosis Factor α ELISA Kit, for cell and tissue lysates,
Species
rat
Canine TNF / Tumor Necrosis Factor ELISA Kit, for serum, plasma and cell culture supernatants,
Species
dog
Bovine TNFα / Tumor Necrosis Factor alpha ELISA Kit, for serum, plasma and cell culture supernatants,
Species
cow

Small Molecule - Antagonist

Product Number
Description
Species
Abietic acid, technical, ~75% (GC),
Species
human
Podocarpic acid, 98%,
Species
human
Forskolin, from Coleus forskohlii, ≥98% (HPLC), powder,
Species
human
SKF-86002, ≥98% (HPLC), solid,
Species
human, rat
Myricetin, ≥96.0% (HPLC),
Species
rat, mouse, human

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-Tumor Necrosis Factor-α antibody produced in mouse, clone 28401, purified immunoglobulin, lyophilized powder,
Species Reactivity
human
Application
ELISA
immunohistochemistry

neutralization

western blot
Anti-Tumor Necrosis Factor-α antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
dot blot
microarray

neutralization
Monoclonal Anti-Tumor Necrosis Factor Receptor II antibody produced in mouse, clone 22221, purified immunoglobulin, lyophilized powder,
Species Reactivity
human
Application
immunocytochemistry
microarray

neutralization
Monoclonal Anti-Tumor Necrosis Factor-α antibody produced in mouse, clone 45418.111, purified immunoglobulin, lyophilized powder,
Species Reactivity
rat
Application
ELISA
neutralization

western blot
Anti-TNFA antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry

Small Molecule - Inhibitor

Product Number
Description
Species
SPD304, ≥98% (HPLC), solid,
Species
mouse, rat, human
SKF-86002, ≥98% (HPLC), solid,
Species
human, rat
Myricetin, ≥96.0% (HPLC),
Species
rat, mouse, human
Myricetin, ≥96.0%, crystalline,
Species
rat, mouse, human
(−)-Thalidomide, >98%, solid,
Species
human, mouse, rat

Proteins

Product Number
Description
Species
Tumor Necrosis Factor-α human, TNF-α, recombinant, expressed in E. coli, powder, suitable for cell culture,
Species
human
Tumor Necrosis Factor-α from rat, TNF-α, recombinant, expressed in E. coli, powder, suitable for cell culture,
Species
rat
Tumor Necrosis Factor-α human, Xeno-free, recombinant, expressed in HEK 293 cells, suitable for cell culture,
Species
human
Tumor Necrosis Factor-α Protein, Recombinant human, Tumor Necrosis Factor-alpha (TNF-alpha) is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells & certain other target cells.,
Species
human
Tumor Necrosis Factor-α, human (hTNF-α), recombinant (yeast),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human TNF,
Species
human
MISSION® esiRNA, targeting mouse Tnf,
Species
mouse