MilliporeSigma

ABI1

abl-interactor 1

Synonyms:
ABI-1, ABLBP4, E3B1, NAP1BP, SSH3BP, SSH3BP1
Species:
UniProtKB ID:
Gene ID:
  • Human(10006) Summary: This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011]
  • Mouse(11308) abl-interactor 1
  • Rat(79249) abl-interactor 1
  • Domestic Rabbit(100349265) abl-interactor 1
  • Horse(100055377) abl-interactor 1
  • domestic guinea pig(100720396) abl-interactor 1
  • naked mole-rat(101724965) abl-interactor 1
  • chicken(420489) abl-interactor 1
  • cow(540815) abl-interactor 1
  • domestic cat(101082922) abl-interactor 1
  • Thale Cress(828714) protein phosphatase 2C 56
  • dog(607247) abl-interactor 1

Custom & Knockdown Gene Products

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  • Custom Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Abl (c-, v-, Bcr-) Antibody, clone 24-21, clone 24-21, from mouse,
Species Reactivity
human
Application
immunocytochemistry
western blot
Anti-phospho-Abi-1 (Ser225) Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
human, monkey, mouse, rat
Application
western blot
Anti-ABI1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-ABI1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
western blot
Anti-phospho-Abl (Tyr412) Antibody, Upstate®, from rabbit,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human ABI1,
Species
human