MilliporeSigma

ADRA2A

adrenoceptor alpha 2A

Synonyms:
ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32
Species:
UniProtKB ID:
Gene ID:
  • Human(150) Summary: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
  • Mouse(11551) adrenergic receptor, alpha 2a
  • Rat(25083) adrenoceptor alpha 2A
  • domestic guinea pig(100135475) adrenergic receptor, alpha 2a
  • chicken(428980) adrenergic, alpha-2A-, receptor
  • sheep(100170317) adrenoceptor alpha 2A
  • Domestic Rabbit(100009424) adrenoceptor alpha 2A
  • Zebrafish(266750) adrenergic, alpha-2A-, receptor
  • dog(486888) adrenoceptor alpha 2A
  • domestic cat(664736) adrenoceptor alpha 2A
  • sheep(101117291) adrenoceptor alpha 2A
  • naked mole-rat(101723298) adrenoceptor alpha 2A
  • cow(282135) adrenergic, alpha-2A-, receptor

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Small Molecule - Agonist

Product Number
Description
Species
Clonidine hydrochloride, British Pharmacopoeia (BP) Reference Standard,
Species
human
p-Iodoclonidine hydrochloride, analytical standard, for drug analysis,
Species
human
(−)-3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine sesquihydrate, 99%,
Species
human
Levonordefrin, United States Pharmacopeia (USP) Reference Standard,
Species
human
Clonidine hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
1-Naphthylmethylamine, 97%,
Species
rat
Idazoxan hydrochloride, ,
Species
human
1,2,3,4-Tetrahydroisoquinoline, 95%,
Species
rat, human
Yohimbine hydrochloride, ≥98% (HPLC), powder,
Species
human
RX 821002 hydrochloride, solid, ≥98% (HPLC),
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-ADRA2A antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
immunofluorescence
Anti-Adrenergic Receptor α-2A antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-ADRA2A antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
canine, human, mouse, rat
Application
ELISA
immunocytochemistry

immunofluorescence
Anti-α2A Adrenergic Receptor antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, pig, rat
Application
immunohistochemistry
western blot

Small Molecule - Blocker

Product Number
Description
Species
Mianserin hydrochloride, ,
Species
human
Agmatine sulfate salt, ≥97%, powder,
Species
human

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
UK 14,304, ,
Species
human
BP897, >98% (HPLC), solid,
Species
human, rat
(−)-Norepinephrine, ≥98%, crystalline,
Species
human, rat
Haloperidol, powder,
Species
human, rat
Clozapine, ,
Species
human, rat

Proteins

Product Number
Description
Species
ChemiSCREEN Human α2A Adrenergic Receptor Membrane Preparation, Human alpha2A GPCR membrane preparation for Radioligand binding Assays & GTPγS binding.,
Species
human