MilliporeSigma

ADRA2C

adrenoceptor alpha 2C

Synonyms:
ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR
Species:
UniProtKB ID:
Gene ID:
  • Human(152) Summary: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
  • Mouse(11553) adrenergic receptor, alpha 2c
  • Rat(24175) adrenoceptor alpha 2C
  • domestic guinea pig(100135477) adrenergic receptor, alpha 2c
  • domestic guinea pig(101787589) adrenoceptor alpha 2C
  • cow(101902575) adrenoceptor alpha 2C
  • cow(407139) alpha-2C adrenergic receptor
  • sheep(100170319) adrenoceptor alpha 2C
  • Zebrafish(266752) adrenergic, alpha-2C-, receptor
  • chicken(428799) adrenergic, alpha-2C-, receptor
  • dog(488793) adrenoceptor alpha 2C
  • domestic cat(101087990) adrenoceptor alpha 2C
  • domestic cat(100529244) adrenoceptor alpha 2C

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Small Molecule - Agonist

Product Number
Description
Species
p-Iodoclonidine hydrochloride, analytical standard, for drug analysis,
Species
human
Clonidine hydrochloride, solid,
Species
human
(−)-3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine sesquihydrate, 99%,
Species
human
Guanabenz acetate, United States Pharmacopeia (USP) Reference Standard,
Species
human
Tizanidine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
Yohimbine hydrochloride, ≥98% (HPLC), powder,
Species
human
Idazoxan hydrochloride, ,
Species
human
RX 821002 hydrochloride, solid, ≥98% (HPLC),
Species
human
UK 14,304, ,
Species
human
Mirtazapine for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Adrenergic Receptor α-2C antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
Monoclonal Anti-Alpha 2C Adrenergic Receptor - Atto 594 antibody produced in mouse, clone S330A-80, purified immunoglobulin,
Species Reactivity
human, mouse
Application
immunocytochemistry
western blot
Monoclonal Anti-Alpha 2C Adrenergic Receptor - Atto 488 antibody produced in mouse, clone S330A-80, purified immunoglobulin,
Species Reactivity
human, mouse
Application
immunocytochemistry
western blot
Monoclonal Anti-Alpha 2C Adrenergic Receptor - Rpe antibody produced in mouse, clone S330A-80, purified immunoglobulin,
Species Reactivity
human, mouse
Application
immunocytochemistry
western blot
Monoclonal Anti-Alpha 2C Adrenergic Receptor - Apc antibody produced in mouse, clone S330A-80, purified immunoglobulin,
Species Reactivity
human, mouse
Application
immunocytochemistry
western blot

Small Molecule - Blocker

Product Number
Description
Species
Mianserin hydrochloride, ,
Species
human
Agmatine sulfate salt, ≥97%, powder,
Species
human

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
UK 14,304, ,
Species
human
(−)-Norepinephrine, ≥98%, crystalline,
Species
human, rat
Haloperidol, powder,
Species
human, rat
Clozapine, ,
Species
human, rat

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Adra2c,
Species
mouse