MilliporeSigma

ATR

ataxia telangiectasia and Rad3 related

Synonyms:
FCTCS, FRP1, MEC1, SCKL, SCKL1
Species:
UniProtKB ID:
Gene ID:
  • Human(545) Summary: The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008]
  • Mouse(245000) ataxia telangiectasia and Rad3 related
  • Rat(685055) ataxia telangiectasia and Rad3 related
  • Thale Cress(834082) serine/threonine-protein kinase ATR
  • Zebrafish(567770) ataxia telangiectasia and Rad3 related
  • chicken(424777) ataxia telangiectasia and Rad3 related
  • dog(477101) ataxia telangiectasia and Rad3 related
  • domestic cat(101088023) ataxia telangiectasia and Rad3 related
  • Horse(100062529) ataxia telangiectasia and Rad3 related
  • cow(504869) ataxia telangiectasia and Rad3 related
  • sheep(101106566) ataxia telangiectasia and Rad3 related
  • Domestic Rabbit(100359062) ataxia telangiectasia and Rad3 related
  • domestic guinea pig(100732693) ataxia telangiectasia and Rad3 related
  • naked mole-rat(101701996) ataxia telangiectasia and Rad3 related

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-ATR, (C-terminal) antibody produced in mouse, clone 1E9, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
Anti-Phospho-ATR-S428 antibody produced in rabbit, ,
Species Reactivity
human
Application
western blot
Anti-ATR antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Rabbit anti-ATR Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.,
Species Reactivity
human
Application
immunoprecipitation (IP)
western blot
Monoclonal Anti-ATR antibody produced in mouse, clone 3F2, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence

western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human ATR,
Species
human
MISSION® esiRNA, targeting mouse Atr,
Species
mouse