MilliporeSigma

CACNA1C

calcium channel, voltage-dependent, L type, alpha 1C subunit

Synonyms:
CACH2, CACN2, CACNL1A1, CCHL1A1, CaV1.2, LQT8, TS
Species:
UniProtKB ID:
Gene ID:
  • Human(775) Summary: This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]
  • Mouse(12288) calcium channel, voltage-dependent, L type, alpha 1C subunit
  • Rat(24239) calcium channel, voltage-dependent, L type, alpha 1C subunit
  • Zebrafish(170581) calcium channel, voltage-dependent, L type, alpha 1C subunit
  • domestic guinea pig(100135490) calcium channel, voltage-dependent, L type, alpha 1C subunit
  • dog(403516) calcium channel, voltage-dependent, L type, alpha 1C subunit
  • naked mole-rat(101717129) calcium channel, voltage-dependent, L type, alpha 1C subunit
  • chicken(395891) calcium channel, voltage-dependent, L type, alpha 1C subunit
  • Horse(100049924) calcium channel, voltage-dependent, L type, alpha 1C subunit
  • domestic cat(101082923) calcium channel, voltage-dependent, L type, alpha 1C subunit
  • cow(408015) calcium channel, voltage-dependent, L type, alpha 1C subunit
  • sheep(101116562) calcium channel, voltage-dependent, L type, alpha 1C subunit
  • Goat(100861292) calcium channel, voltage-dependent, L type, alpha 1C subunit

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Small Molecule - Allosteric Modulator

Product Number
Description
Species
Pregabalin, European Pharmacopoeia (EP) Reference Standard,
Species
human
Gabapentin solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Gabapentin, European Pharmacopoeia (EP) Reference Standard,
Species
human
Gabapentin, United States Pharmacopeia (USP) Reference Standard,
Species
human
Gabapentin, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
(±)-Bay K8644, calcium channel agonist,
Species
rat
Felodipine, British Pharmacopoeia (BP) Reference Standard,
Species
human
Felodipine, United States Pharmacopeia (USP) Reference Standard,
Species
human
Felodipine, European Pharmacopoeia (EP) Reference Standard,
Species
human
Nimodipine, United States Pharmacopeia (USP) Reference Standard,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Calcium Channel Antibody, Voltage Gated α 1C, Chemicon®, from rabbit,
Species Reactivity
human, mouse, rabbit, rat
Application
immunohistochemistry
immunoprecipitation (IP)

western blot
Anti-Calcium Channel (α1C Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rabbit, rat
Application
immunohistochemistry
western blot
Anti-CACNA1C antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Anti-Calcium Channel (Cardiac α1C Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Species Reactivity
rabbit, rat
Application
immunoprecipitation (IP)
western blot
Anti-Cav1.2 alpha1c, clone 8F9.1 Antibody, clone 8F9.1, from mouse,
Species Reactivity
human
Application
immunohistochemistry
western blot

Small Molecule - Blocker

Product Number
Description
Species
Amlodipine besylate, European Pharmacopoeia (EP) Reference Standard,
Species
human
Diltiazem hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Species
human
Amlodipine besylate, United States Pharmacopeia (USP) Reference Standard,
Species
human
Diltiazem impurity standard, British Pharmacopoeia (BP) Reference Standard,
Species
human
Diltiazem hydrochloride, British Pharmacopoeia (BP) Reference Standard,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Cacna1c,
Species
mouse
MISSION® esiRNA, targeting human CACNA1C (1),
Species
human
MISSION® esiRNA, targeting human CACNA1C (2),
Species
human