MilliporeSigma

CLDN18

claudin 18

Synonyms:
SFTA5, SFTPJ
Species:
UniProtKB ID:
Gene ID:
  • Human(51208) Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]
  • Mouse(56492) claudin 18
  • Rat(315953) claudin 18
  • naked mole-rat(101705422) claudin 18
  • cow(511460) claudin 18
  • domestic guinea pig(100730947) claudin 18
  • chicken(429135) claudin 18
  • dog(477079) claudin 18
  • sheep(101112106) claudin 18
  • domestic cat(101093797) claudin 18

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

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  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-CLDN18 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, human, mouse, pig, rabbit, rat
Application
western blot
Anti-CLDN18, affinity isolated antibody,
Species Reactivity
horse, human, mouse, rat
Application
western blot
Anti-CLDN18 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human CLDN18,
Species
human