MilliporeSigma

CYP7A1

cytochrome P450, family 7, subfamily A, polypeptide 1

Synonyms:
CP7A, CYP7, CYPVII
Species:
UniProtKB ID:
Gene ID:
  • Human(1581) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010]
  • Mouse(13122) cytochrome P450, family 7, subfamily a, polypeptide 1
  • Rat(25428) cytochrome P450, family 7, subfamily a, polypeptide 1
  • domestic guinea pig(100337633) cholesterol 7-alpha-hydroxylase
  • Domestic Rabbit(100328551) cytochrome P450, family 7, subfamily A, polypeptide 1
  • dog(486962) cytochrome P450, family 7, subfamily A, polypeptide 1
  • chicken(414834) cytochrome P450, family 7, subfamily A, polypeptide 1
  • cow(510507) cytochrome P450, family 7, subfamily A, polypeptide 1

Custom & Knockdown Gene Products

  • siRNA

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  • Custom Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Cyp7a1 Antibody, clone 15B9.1, clone 15B9.1, from mouse,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-CYP7A1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry

Small Molecule - Inhibitor

Product Number
Description
Species
Ketoconazole, 99.0-101.0% (EP, titration),
Species
mouse, human, rat
Ketoconazole, ,
Species
mouse, human, rat

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Cyp7a1,
Species
mouse
MISSION® esiRNA, targeting human CYP7A1,
Species
human