MilliporeSigma

ERBB3

v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

Synonyms:
ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3
Species:
UniProtKB ID:
Gene ID:
  • Human(2065) Summary: This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
  • Mouse(13867) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
  • Rat(29496) v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
  • cow(785655) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
  • dog(481105) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
  • domestic guinea pig(100712946) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
  • chicken(693245) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3
  • sheep(101103889) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
  • Domestic Rabbit(100008807) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
  • Horse(100059216) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
  • domestic cat(101085388) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
  • naked mole-rat(101721671) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

Custom & Knockdown Gene Products

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ELISA

Product Number
Description
Species
Human ErbB3 / HER3 ELISA Kit, for serum, plasma, cell culture supernatant and urine,
Species
human
Phosphotyrosine ERBB3 / Receptor Tyrosine-protein Kinase erbB-3 ELISA Kit, ,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-C-ERBB3 antibody, Rabbit monoclonal, recombinant, expressed in proprietary host, clone SP71, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
Anti-phospho-HER3 (pTyr1222) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-phospho-HER3 (pTyr1289) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
Monoclonal Anti-ERBB3 antibody produced in mouse, clone 2E9, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Anti-HER3 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot

Proteins

Product Number
Description
Species
ErbB3/HER3 human, recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Erbb3,
Species
mouse
MISSION® esiRNA, targeting human ERBB3,
Species
human