MilliporeSigma

EWSR1

EWS RNA-binding protein 1

Synonyms:
EWS, bK984G1.4
Species:
UniProtKB ID:
Gene ID:
  • Human(2130) Summary: This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009]
  • Mouse(14030) Ewing sarcoma breakpoint region 1
  • Rat(289752) EWS RNA-binding protein 1
  • naked mole-rat(101697325) EWS RNA-binding protein 1
  • domestic guinea pig(100718262) EWS RNA-binding protein 1
  • chicken(417022) Ewing sarcoma breakpoint region 1
  • sheep(101121203) Ewing sarcoma breakpoint region 1
  • cow(534073) Ewing sarcoma breakpoint region 1
  • Horse(100034010) Ewing sarcoma breakpoint region 1
  • domestic cat(101093398) Ewing sarcoma breakpoint region 1
  • dog(609786) Ewing sarcoma breakpoint region 1

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-EWSR1 antibody produced in rabbit, ,
Species Reactivity
human
Application
immunohistochemistry
western blot
Monoclonal Anti-EWSR1 antibody produced in mouse, clone 3A9, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence

western blot
Anti-EWSR1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

western blot
Anti-EWSR1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-EWSR1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse EWSR1,
Species
mouse
MISSION® esiRNA, targeting human EWSR1,
Species
human