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FLT1

fms-related tyrosine kinase 1

Synonyms:
FLT, FLT-1, VEGFR-1, VEGFR1
Species:
UniProtKB ID:
Gene ID:
  • Human(2321) Summary: This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]
  • Mouse(14254) FMS-like tyrosine kinase 1
  • Rat(54251) FMS-related tyrosine kinase 1
  • domestic guinea pig(100732326) fms-related tyrosine kinase 1
  • Zebrafish(544667) fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
  • dog(403727) fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
  • domestic cat(101088292) fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
  • sheep(443088) fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
  • chicken(374100) fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
  • Horse(100061940) fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
  • cow(503620) fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
  • Domestic Rabbit(100343352) fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
  • Horse(100033957) fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
  • naked mole-rat(101711333) fms-related tyrosine kinase 1

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ELISA

Product Number
Description
Species
Human VEGFR1 ELISA Kit, for cell culture supernatants, plasma, and serum samples,
Species
human
Rat VEGFR1 ELISA, for serum, plasma and cell culture supernatants,
Species
rat

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-Vascular Endothelial Growth Factor Receptor-1 antibody produced in mouse, clone FLT-19, tissue culture supernatant,
Species Reactivity
human
Application
ELISA
immunohistochemistry

immunoprecipitation (IP)

microarray
Anti-phospho-VEGFR1 (pTyr1333) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot
Monoclonal Anti-Vascular Endothelial Growth Factor Receptor-1 antibody produced in mouse, clone FLT-11, ascites fluid,
Species Reactivity
human
Application
ELISA
immunocytochemistry

immunohistochemistry

immunoprecipitation (IP)

western blot
Monoclonal Anti-FLT1 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL0345, purified immunoglobulin, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-VEGFR1 Antibody, clone 7F1A3, Rabbit Monoclonal, ,
Species Reactivity
mouse, rat
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
SU 4312, ≥98% (HPLC),
Species
human
Axitinib, ≥98% (HPLC),
Species
human
SU 5416, ≥98% (HPLC),
Species
human, mouse
Sunitinib malate, ≥98% (HPLC),
Species
human
Pazopanib, ,
Species
human

Proteins

Product Number
Description
Species
VEGF Receptor-1 (Flt-1)/Fc Chimera human, >90% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder,
Species
human
Flt1 active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE),
Species
human
FLT1 (784-end), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human FLT1,
Species
human