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HEXA

hexosaminidase A (alpha polypeptide)

Synonyms:
TSD
Species:
UniProtKB ID:
Gene ID:
  • Human(3073) Summary: This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I). [provided by RefSeq, Jul 2009]
  • Mouse(15211) hexosaminidase A
  • Rat(300757) hexosaminidase A
  • chicken(415320) hexosaminidase A (alpha polypeptide)
  • Zebrafish(323613) hexosaminidase A (alpha polypeptide)
  • domestic guinea pig(100712955) hexosaminidase A (alpha polypeptide)
  • naked mole-rat(101718368) hexosaminidase A (alpha polypeptide)
  • domestic cat(101091627) hexosaminidase A (alpha polypeptide)
  • dog(487633) hexosaminidase A (alpha polypeptide)
  • Horse(100063584) hexosaminidase A (alpha polypeptide)
  • sheep(100145856) hexosaminidase A (alpha polypeptide)
  • cow(504468) hexosaminidase A (alpha polypeptide)
  • Domestic Rabbit(100008950) hexosaminidase A (alpha polypeptide)

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ELISA

Product Number
Description
Species
Human HEXA ELISA, for serum, plasma and cell culture supernatants,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-HEXA antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-HEXA (C-terminal) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, canine, guinea pig, horse, human, mouse, pig, rabbit, sheep
Application
immunohistochemistry
western blot
Anti-HEXA antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence

Small Molecule - Inhibitor

Product Number
Description
Species
(±)-Taxifolin hydrate, ≥90% (HPLC),
Species
mouse
Quercetin 3-β-D-glucoside, ≥90% (HPLC),
Species
mouse
3-Hydroxyflavone, ≥98%,
Species
mouse
Quercetin 3-D-galactoside, ≥97.0% (HPLC),
Species
mouse
Baicalin, 95%,
Species
mouse

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human HEXA,
Species
human