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KCNH2

potassium voltage-gated channel, subfamily H (eag-related), member 2

Synonyms:
ERG1, HERG, HERG1, Kv11.1, LQT2, SQT1
Species:
UniProtKB ID:
Gene ID:
  • Human(3757) Summary: This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
  • Mouse(16511) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • Rat(117018) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • Zebrafish(405763) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • naked mole-rat(101711977) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • domestic cat(101081621) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • Horse(100064000) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • Domestic Rabbit(100009242) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • dog(403761) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • domestic guinea pig(100135563) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • cow(539971) potassium voltage-gated channel, subfamily H (eag-related), member 2

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Small Molecule - Antagonist

Product Number
Description
Species
Sotalol hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Species
human
Sotalol hydrochloride, British Pharmacopoeia (BP) Reference Standard,
Species
human
(±)-Sotalol hydrochloride, ≥98% (TLC), powder,
Species
human
Glyburide, meets USP testing specifications,
Species
rat, human
Glybenclamide, ≥99% (HPLC),
Species
rat, human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Potassium Channel HERG Antibody, CT, Chemicon®, from rabbit,
Species Reactivity
human
Application
immunocytochemistry
immunoprecipitation (IP)

western blot
Anti-KCNH2 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
Anti-Potassium Channel Kv11.1 (HERG) Extracellular−FITC antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Species Reactivity
human
Application
flow cytometry
immunocytochemistry
Anti-Potassium Channel ERG1 Antibody, CT, Chemicon®, from rabbit,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-Potassium Channel Kv11.1 Extracellular antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Species Reactivity
human
Application
flow cytometry
immunocytochemistry

western blot

Small Molecule - Blocker

Product Number
Description
Species
Ibutilide hemifumarate salt, ≥98% (HPLC),
Species
human
Amiodarone hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Ibutilide fumarate, United States Pharmacopeia (USP) Reference Standard, monograph mol wt. 885.23 ([(C20H36N2O3S)2 . C4H4O4]),
Species
human
Dofetilide, United States Pharmacopeia (USP) Reference Standard,
Species
human
Sotalol hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Species
human

Small Molecule - Inhibitor

Product Number
Description
Species
Loratadine, ≥98% (HPLC), powder,
Species
rat, human
Terfenadine, ,
Species
mouse, rat, human
Cocaine free base, ,
Species
mouse, rat, human
Pimozide, ,
Species
human, mouse, rat
Haloperidol, powder,
Species
human, rat

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human KCNH2,
Species
human